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10.3906/sag-2006-96

http://scihub22266oqcxt.onion/10.3906/sag-2006-96
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suck abstract from ncbi


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pmid32979900      Turk+J+Med+Sci 2020 ; 50 (8): 1786-1791
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  • The assessment of the serum levels of TWEAK and prostaglandin F2alpha in COVID - 19 #MMPMID32979900
  • Yalcin Kehribar D; Cihangiroglu M; Sehmen E; Avci B; Capraz M; Boran M; Gunaydin C; Ozgen M
  • Turk J Med Sci 2020[Dec]; 50 (8): 1786-1791 PMID32979900show ga
  • BACKGROUND/AIM: It is claimed that aberrant immune response has a more important role than the cytopathic effect of the virus in the morbidity and mortality of the coronavirus disease 2019 (COVID-19). We aimed to investigate the possible roles of tumor necrosis factor-like weak inducer of apoptosis (TWEAK)/Fn14 pathway and leukotrienes (LT) in uncontrolled immune response that occurs in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). MATERIALS AND METHODS: This study included 25 asymptomatic patients and 35 patients with lung involvement who were diagnosed with COVID-19 as well as 22 healthy volunteers. Lung involvement was determined using computed-tomography. Serum TWEAK, LTE4, and prostaglandin F2alpha (PGF2alpha) levels were determined. RESULTS: Compared with the healthy control group, TWEAK, LTE4, and PGF2alpha levels were higher in the group of SARS-CoV-2 infection without lung involvement. In the group of SARS-CoV-2 infection with lung involvement, age, fibrinogen, sedimentation, C-reactive protein and ferritin, TWEAK, LTE4, and PGF2alpha levels were higher, and lymphocyte levels were lower compared with the asymptomatic group. CONCLUSIONS: In the study, TWEAK and LTE4 levels increased in cases with COVID-19. These results support that TWEAK/Fn14 pathway and LT may involved in the pathology of aberrant immune response against SARS-CoV-2. Inhibition of each of these pathways may be a potential target in the treatment of COVID-19.
  • |*COVID-19/diagnosis/immunology[MESH]
  • |Correlation of Data[MESH]
  • |Cytokine TWEAK/*blood[MESH]
  • |Dinoprost/*blood[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Leukotriene E4/*blood[MESH]
  • |Lung/*diagnostic imaging[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Signal Transduction/immunology[MESH]


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