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10.1016/j.cmi.2020.09.021

http://scihub22266oqcxt.onion/10.1016/j.cmi.2020.09.021
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32979572!7510451!32979572
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suck abstract from ncbi


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pmid32979572      Clin+Microbiol+Infect 2021 ; 27 (2): 238-243
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  • Effects of tocilizumab on mortality in hospitalized patients with COVID-19: a multicentre cohort study #MMPMID32979572
  • Martinez-Sanz J; Muriel A; Ron R; Herrera S; Perez-Molina JA; Moreno S; Serrano-Villar S
  • Clin Microbiol Infect 2021[Feb]; 27 (2): 238-243 PMID32979572show ga
  • OBJECTIVES: Tocilizumab has been proposed as a candidate therapy for patients with severe coronavirus disease 2019 (COVID-19), especially among those with higher systemic inflammation. We investigated the association between receipt of tocilizumab and mortality in a large cohort of hospitalized patients. METHODS: In this cohort study of patients hospitalized with COVID-19 in Spain, the primary outcome was time to death and the secondary outcome time to intensive care unit (ICU) admission or death. We used inverse probability weighting to fit marginal structural models adjusted for time-varying covariates to determine the causal relationship between receipt of tocilizumab and outcome. RESULTS: Data from 1229 patients were analysed, with 261 patients (61 deaths) in the tocilizumab group and 969 patients (120 deaths) in the control group. In the adjusted marginal structural models, a significant interaction between receipt of tocilizumab and high C-reactive protein (CRP) levels was detected. Tocilizumab was associated with decreased risk of death (adjusted hazard ratio 0.34, 95% confidence interval 0.16-0.72, p 0.005) and ICU admission or death (adjusted hazard ratio 0.39, 95% confidence interval 0.19-0.80, p 0.011) among patients with baseline CRP >150 mg/L but not among those with CRP
  • |*COVID-19 Drug Treatment[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Antibodies, Monoclonal, Humanized/*therapeutic use[MESH]
  • |C-Reactive Protein/metabolism[MESH]
  • |COVID-19/mortality/pathology[MESH]
  • |Cohort Studies[MESH]
  • |Female[MESH]
  • |Hospital Mortality[MESH]
  • |Hospitalization/*statistics & numerical data[MESH]
  • |Humans[MESH]
  • |Intensive Care Units/statistics & numerical data[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |SARS-CoV-2[MESH]
  • |Spain/epidemiology[MESH]


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