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10.1016/j.virusres.2020.198171 http://scihub22266oqcxt.onion/10.1016/j.virusres.2020.198171 32979474!7510544!32979474     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32979474&cmd=llinks): Failed to open stream: HTTP request failed! 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IFN-gamma is an independent risk factor associated with mortality in patients with moderate and severe COVID-19 infection |pdf=|usr=}}{{32979474}} gab.com Text IFN-gamma is an independent risk factor associated with mortality in patients with moderate and severe COVID-19 infection JO: Virus Res http://www.kidney.de/pget.php?&tw=1&pmid=32979474 #FOAvip BACKGROUND: Innate and adaptive immune responses have been evaluated in infected patients with COVID-19. The severity of the disease has been supposed to be associated with some profile not reported with other bacterial and viral pneumonia. We proposed a study in patients with moderate to severe COVID-19 infection to evaluate the interleukin patterns and its role as prognosis factors. METHODS: A prospective cohort with moderate and severe cases of COVID-19 infection from June to July 2020. Blood samples from patients were collected regularly to evaluate IFN-gamma, TNF-alpha, IL-4, IL-6, and IL-10. Clinical, laboratory, radiological data, and outcomes were recorded. The outcome variable was in-hospital death, survival, mechanical ventilation, and admission at the intensive care unit. Data are presented in median and interquartile range [IQR]. RESULTS: We evaluated the Th1 and Th2 responses according to evolution, distinguishing possible predictive markers. The IFN-gamma median of 323 pg/mL [IQR 166-570] was found in patients who died and 208 pg/mL [IQR 155-392] in the survival group (p = 0.017). IFN-gamma was also higher in the early stages of the disease (394 pg/mL [IQR 229-575] against 162 pg/mL [IQR 117-259], p < 0.001). IL-4 that was increased in late-stage (182 pg/mL [IQR 162-199] against 131 pg/mL [IQR 124-152], p < 0.001) but not associated with mortality. Also, death was also related to male gender (relative risk = 1.5 [95 % confidence interval = 1.1-2.0]). CONCLUSION: Our results suggest that the activation of the host immune response between Th1 or Th2 in COVID-19 infection may be related to the final result between discharge or death. This implies an attempt to control cytokines, such as IFN-gamma, with combined therapies for clinical treatment. Twit Text FOAVip IFN-gamma is an independent risk factor associated with mortality in patients with moderate and severe COVID-19 infection ????Virus Res http://www.kidney.de/pget.php?&tw=1&pmid=32979474 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32979474 #FOAvip English Wikipedia <ref>{{Cite pmid|32979474}}</ref> IFN-gamma is an independent risk factor associated with mortality in patients with moderate and severe COVID-19 infection #MMPMID32979474 Gadotti AC; de Castro Deus M; Telles JP; Wind R; Goes M; Garcia Charello Ossoski R; de Padua AM; de Noronha L; Moreno-Amaral A; Baena CP; Tuon FF Virus Res 2020[Nov]; 289 (ä): 198171 PMID32979474show ga BACKGROUND: Innate and adaptive immune responses have been evaluated in infected patients with COVID-19. The severity of the disease has been supposed to be associated with some profile not reported with other bacterial and viral pneumonia. We proposed a study in patients with moderate to severe COVID-19 infection to evaluate the interleukin patterns and its role as prognosis factors. METHODS: A prospective cohort with moderate and severe cases of COVID-19 infection from June to July 2020. Blood samples from patients were collected regularly to evaluate IFN-gamma, TNF-alpha, IL-4, IL-6, and IL-10. Clinical, laboratory, radiological data, and outcomes were recorded. The outcome variable was in-hospital death, survival, mechanical ventilation, and admission at the intensive care unit. Data are presented in median and interquartile range [IQR]. RESULTS: We evaluated the Th1 and Th2 responses according to evolution, distinguishing possible predictive markers. The IFN-gamma median of 323 pg/mL [IQR 166-570] was found in patients who died and 208 pg/mL [IQR 155-392] in the survival group (p = 0.017). IFN-gamma was also higher in the early stages of the disease (394 pg/mL [IQR 229-575] against 162 pg/mL [IQR 117-259], p < 0.001). IL-4 that was increased in late-stage (182 pg/mL [IQR 162-199] against 131 pg/mL [IQR 124-152], p < 0.001) but not associated with mortality. Also, death was also related to male gender (relative risk = 1.5 [95 % confidence interval = 1.1-2.0]). CONCLUSION: Our results suggest that the activation of the host immune response between Th1 or Th2 in COVID-19 infection may be related to the final result between discharge or death. This implies an attempt to control cytokines, such as IFN-gamma, with combined therapies for clinical treatment. |*Betacoronavirus[MESH] |*Pandemics[MESH] |Aged[MESH] |COVID-19[MESH] |Comorbidity[MESH] |Coronavirus Infections/blood/complications/immunology/*mortality[MESH] |Cytokine Release Syndrome/blood/etiology[MESH] |Cytokines/blood[MESH] |Disease Progression[MESH] |Female[MESH] |Hospital Mortality[MESH] |Humans[MESH] |Immunity, Innate[MESH] |Inpatients/statistics & numerical data[MESH] |Intensive Care Units/statistics & numerical data[MESH] |Interferon-gamma/blood/*physiology[MESH] |Male[MESH] |Middle Aged[MESH] |Pneumonia, Viral/blood/complications/immunology/*mortality[MESH] |Prognosis[MESH] |Prospective Studies[MESH] |Respiration, Artificial[MESH] |Risk Factors[MESH] |SARS-CoV-2[MESH] |Th1 Cells/immunology[MESH]IFN-gamma is an independent risk factor associated with mortality in p(epmc).pdf DeepDyve Pubget Overpricing