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10.1016/j.jaci.2020.09.009

http://scihub22266oqcxt.onion/10.1016/j.jaci.2020.09.009
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32979342!7581505!32979342
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suck abstract from ncbi


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pmid32979342      J+Allergy+Clin+Immunol 2021 ; 147 (1): 81-91
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  • Compartmental immunophenotyping in COVID-19 ARDS: A case series #MMPMID32979342
  • Ronit A; Berg RMG; Bay JT; Haugaard AK; Ahlstrom MG; Burgdorf KS; Ullum H; Rorvig SB; Tjelle K; Foss NB; Benfield T; Marquart HV; Plovsing RR
  • J Allergy Clin Immunol 2021[Jan]; 147 (1): 81-91 PMID32979342show ga
  • BACKGROUND: Severe immunopathology may drive the deleterious manifestations that are observed in the advanced stages of coronavirus disease 2019 (COVID-19) but are poorly understood. OBJECTIVE: Our aim was to phenotype leukocyte subpopulations and the cytokine milieu in the lungs and blood of critically ill patients with COVID-19 acute respiratory distress syndrome (ARDS). METHODS: We consecutively included patients less than 72 hours after intubation following informed consent from their next of kin. Bronchoalveolar lavage fluid was evaluated by microscopy; bronchoalveolar lavage fluid and blood were assessed by 10-color flow cytometry and a multiplex cytokine panel. RESULTS: Four mechanically ventilated patients (aged 40-75 years) with moderate-to-severe COVID-19 ARDS were included. Immature neutrophils dominated in both blood and lungs, whereas CD4 and CD8 T-cell lymphopenia was observed in the 2 compartments. However, regulatory T cells and T(H)17 cells were found in higher fractions in the lung. Lung CD4 and CD8 T cells and macrophages expressed an even higher upregulation of activation markers than in blood. A wide range of cytokines were expressed at high levels both in the blood and in the lungs, most notably, IL-1RA, IL-6, IL-8, IP-10, and monocyte chemoattactant protein-1, consistent with hyperinflammation. CONCLUSION: COVID-19 ARDS exhibits a distinct immunologic profile in the lungs, with a depleted and exhausted CD4 and CD8 T-cell population that resides within a heavily hyperinflammatory milieu.
  • |Adult[MESH]
  • |Aged[MESH]
  • |CD8-Positive T-Lymphocytes/*immunology/pathology[MESH]
  • |COVID-19/*immunology/pathology[MESH]
  • |Cross-Sectional Studies[MESH]
  • |Cytokines/immunology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Immunophenotyping[MESH]
  • |Lung/*immunology/pathology[MESH]
  • |Lymphopenia/*immunology/pathology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Respiratory Distress Syndrome/*immunology/pathology[MESH]
  • |SARS-CoV-2/*immunology[MESH]


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