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10.1074/jbc.AC120.015967 http://scihub22266oqcxt.onion/10.1074/jbc.AC120.015967 32978255!7650240!32978255     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Biol+Chem 2020 ; 295 (45): 15418-15422 Nephropedia Template TP {{tp|p=32978255|t=2020. Presence of hyaluronan in lung alveoli in severe Covid-19: An opening for new treatment options?|pdf=|usr=}}{{32978255}} gab.com Text Presence of hyaluronan in lung alveoli in severe Covid-19: An opening for new treatment options JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=32978255 #FOAvip Severe coronavirus disease 2019 (Covid-19) is characterized by inflammation of the lungs with increasing respiratory impairment. In fatal Covid-19, lungs at autopsy have been filled with a clear liquid jelly. However, the nature of this finding has not yet been determined. The aim of the study was to demonstrate whether the lungs of fatal Covid-19 contain hyaluronan, as it is associated with inflammation and acute respiratory distress syndrome (ARDS) and may have the appearance of liquid jelly. Lung tissue obtained at autopsy from three deceased Covid-19 patients was processed for hyaluronan histochemistry using a direct staining method and compared with staining in normal lung tissue. Stainings confirmed that hyaluronan is obstructing alveoli with presence in exudate and plugs, as well as in thickened perialveolar interstitium. In contrast, normal lungs only showed hyaluronan in intact alveolar walls and perivascular tissue. This is the first study to confirm prominent hyaluronan exudates in the alveolar spaces of Covid-19 lungs, supporting the notion that the macromolecule is involved in ARDS caused by SARS-CoV-2. The present finding may open up new treatment options in severe Covid-19, aiming at reducing the presence and production of hyaluronan in the lungs. Twit Text FOAVip Presence of hyaluronan in lung alveoli in severe Covid-19: An opening for new treatment options ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=32978255 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32978255 #FOAvip English Wikipedia <ref>{{Cite pmid|32978255}}</ref> Presence of hyaluronan in lung alveoli in severe Covid-19: An opening for new treatment options? #MMPMID32978255 Hellman U; Karlsson MG; Engstrom-Laurent A; Cajander S; Dorofte L; Ahlm C; Laurent C; Blomberg A J Biol Chem 2020[Nov]; 295 (45): 15418-15422 PMID32978255show ga Severe coronavirus disease 2019 (Covid-19) is characterized by inflammation of the lungs with increasing respiratory impairment. In fatal Covid-19, lungs at autopsy have been filled with a clear liquid jelly. However, the nature of this finding has not yet been determined. The aim of the study was to demonstrate whether the lungs of fatal Covid-19 contain hyaluronan, as it is associated with inflammation and acute respiratory distress syndrome (ARDS) and may have the appearance of liquid jelly. Lung tissue obtained at autopsy from three deceased Covid-19 patients was processed for hyaluronan histochemistry using a direct staining method and compared with staining in normal lung tissue. Stainings confirmed that hyaluronan is obstructing alveoli with presence in exudate and plugs, as well as in thickened perialveolar interstitium. In contrast, normal lungs only showed hyaluronan in intact alveolar walls and perivascular tissue. This is the first study to confirm prominent hyaluronan exudates in the alveolar spaces of Covid-19 lungs, supporting the notion that the macromolecule is involved in ARDS caused by SARS-CoV-2. The present finding may open up new treatment options in severe Covid-19, aiming at reducing the presence and production of hyaluronan in the lungs. |COVID-19/*metabolism/pathology[MESH] |Humans[MESH] |Hyaluronic Acid/*metabolism[MESH] |Lung/*metabolism/pathology[MESH] |Male[MESH]Presence of hyaluronan in lung alveoli in severe Covid-19: An opening (epmc).pdf DeepDyve Pubget Overpricing