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Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Diagn+Microbiol+Infect+Dis 2021 ; 99 (1): 115197 Nephropedia Template TP
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Comparison of 2 fully automated tests detecting antibodies against nucleocapsid N and spike S1/S2 proteins in COVID-19 #MMPMID32977117
Diagn Microbiol Infect Dis 2021[Jan]; 99 (1): 115197 PMID32977117show ga
Automated assays for detecting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies in coronavirus disease 2019 (COVID-19) diagnostics have recently come available. We compared the performance of the Elecsys(R) Anti-SARS-CoV-2 and LIAISON(R) SARS-CoV-2?S1/S2 IgG tests. The seroconversion panel comprised of 120 samples from 13 hospitalized COVID-19 patients. For the sensitivity and specificity testing, samples from COVID-19 outpatients >15?days after positive nucleic acid amplification test (NAAT) result (n?=?35) and serum control samples collected before the COVID-19 era (n?=?161) were included in the material. Samples for the detection of possible cross-reactions were also tested. Based on our results, the SARS-CoV-2 antibodies can be quite reliably detected 2?weeks after NAAT positivity and 3?weeks after the symptom onset with both tests. However, since some COVID-19 patients were positive only with Elecsys(R), the antibodies should be screened against N-antigen (Elecsys(R)) and reactive samples confirmed with S antigen (LIAISON(R)), but both results should be reported. In some COVID-19 patients, the serology can remain negative.