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10.1371/journal.pone.0239532

http://scihub22266oqcxt.onion/10.1371/journal.pone.0239532
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32976531!7518571!32976531
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suck abstract from ncbi


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pmid32976531      PLoS+One 2020 ; 15 (9): e0239532
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  • The changes of the peripheral CD4+ lymphocytes and inflammatory cytokines in Patients with COVID-19 #MMPMID32976531
  • Sun HB; Zhang YM; Huang LG; Lai QN; Mo Q; Ye XZ; Wang T; Zhu ZZ; Lv XL; Luo YJ; Gao SD; Xu JS; Zhu HH; Li T; Wang ZK
  • PLoS One 2020[]; 15 (9): e0239532 PMID32976531show ga
  • To investigate the clinical value of changes in the subtypes of peripheral blood lymphocytes and levels of inflammatory cytokines in patients with COVID-19, the total numbers of lymphocytes and CD4+ lymphocytes and the ratio of CD4+/CD8+ lymphocytes were calculated and observed in different groups of patients with COVID-19. The results show that the lymphocytopenia in patients with COVID-19 was mainly manifested by decreases in the CD4+ T lymphocyte number and the CD4+/CD8+ ratio. The decreased number of CD4+ T lymphocytes and the elevated levels of TNF-alpha and IL-6 were correlated with the severity of COVID-19 disease.
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Betacoronavirus[MESH]
  • |CD4 Lymphocyte Count[MESH]
  • |CD4-CD8 Ratio[MESH]
  • |CD4-Positive T-Lymphocytes/*pathology[MESH]
  • |COVID-19[MESH]
  • |Child[MESH]
  • |Coronavirus Infections/*blood/diagnosis/*immunology[MESH]
  • |Cytokines/*blood[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Interleukin-6/blood[MESH]
  • |Lymphopenia/blood/pathology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*blood/diagnosis/*immunology[MESH]
  • |SARS-CoV-2[MESH]
  • |Severity of Illness Index[MESH]


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