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10.1172/JCI143331 http://scihub22266oqcxt.onion/10.1172/JCI143331 32976118!7685752!32976118     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Invest 2020 ; 130 (12): 6218-6221 Nephropedia Template TP {{tp|p=32976118|t=2020. Corticosteroids, COVID-19 pneumonia, and acute respiratory distress syndrome |pdf=|usr=}}{{32976118}} gab.com Text Corticosteroids, COVID-19 pneumonia, and acute respiratory distress syndrome JO: J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=32976118 #FOAvip Although corticosteroids dampen the dysregulated immune system and sometimes are prescribed as an adjunctive treatment for pneumonia, their effectiveness in the treatment of coronavirus disease 2019 (COVID-19) remains controversial. In this issue of the JCI, Liu and Zhang et al. evaluated corticosteroid treatment in more than 400 patients with severe COVID-19. The authors assessed subjects retrospectively for cardiac and liver injury, shock, ventilation, mortality, and viral clearance. Corticosteroids in severe COVID-19-related acute respiratory distress syndrome (ARDS) were associated with increased mortality and delayed viral clearance. Here, we consider how to reconcile the negative effects of corticosteroids revealed by Liu and Zhang et al. with the favorable effects (reduced mortality) that were described in the RECOVERY trial. We posit that treatment timing, dosage, and COVID-19 severity determine immune response and viral outcome. Patients with moderate-to-severe COVID-19 pneumonia are likely to benefit from moderate-dose corticosteroid treatment when administered relatively late in the disease course. Twit Text FOAVip Corticosteroids, COVID-19 pneumonia, and acute respiratory distress syndrome ????J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=32976118 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32976118 #FOAvip English Wikipedia <ref>{{Cite pmid|32976118}}</ref> Corticosteroids, COVID-19 pneumonia, and acute respiratory distress syndrome #MMPMID32976118 Matthay MA; Wick KD J Clin Invest 2020[Dec]; 130 (12): 6218-6221 PMID32976118show ga Although corticosteroids dampen the dysregulated immune system and sometimes are prescribed as an adjunctive treatment for pneumonia, their effectiveness in the treatment of coronavirus disease 2019 (COVID-19) remains controversial. In this issue of the JCI, Liu and Zhang et al. evaluated corticosteroid treatment in more than 400 patients with severe COVID-19. The authors assessed subjects retrospectively for cardiac and liver injury, shock, ventilation, mortality, and viral clearance. Corticosteroids in severe COVID-19-related acute respiratory distress syndrome (ARDS) were associated with increased mortality and delayed viral clearance. Here, we consider how to reconcile the negative effects of corticosteroids revealed by Liu and Zhang et al. with the favorable effects (reduced mortality) that were described in the RECOVERY trial. We posit that treatment timing, dosage, and COVID-19 severity determine immune response and viral outcome. Patients with moderate-to-severe COVID-19 pneumonia are likely to benefit from moderate-dose corticosteroid treatment when administered relatively late in the disease course. |*Betacoronavirus[MESH] |*COVID-19[MESH] |*Coronavirus Infections[MESH] |*Pneumonia, Viral[MESH] |*Respiratory Distress Syndrome[MESH] |Adrenal Cortex Hormones[MESH] |Humans[MESH] |Pandemics[MESH] |Retrospective Studies[MESH]Corticosteroids, COVID-19 pneumonia, and acute respiratory distress sy(epmc).pdf DeepDyve Pubget Overpricing