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10.1172/JCI142081 http://scihub22266oqcxt.onion/10.1172/JCI142081 32976117!7685712!32976117     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Invest 2020 ; 130 (12): 6222-6224 Nephropedia Template TP {{tp|p=32976117|t=2020. Are T cells helpful for COVID-19: the relationship between response and risk |pdf=|usr=}}{{32976117}} gab.com Text Are T cells helpful for COVID-19: the relationship between response and risk JO: J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=32976117 #FOAvip The disease spectrum of coronavirus disease 2019 (COVID-19) ranges from no symptoms to multisystem failure and death. Characterization of virus-specific immune responses to severe acute respiratory coronavirus 2 (SARS-CoV-2) is key to understanding disease pathogenesis, but few studies have evaluated T cell immunity. In this issue of the JCI, Sattler and Angermair et al. sampled blood from subjects with COVID-19 and analyzed the activation and function of virus antigen-specific CD4+ T cells. T cells that failed to respond to peptides from the membrane, spike, or nucleocapsid proteins were more common in subjects who died. In those whose T cells had the capacity to respond, older patients with comorbidity had larger numbers of activated T cells compared with patients who had fewer risk factors, but these cells showed impaired IFN-gamma production. This cross-sectional study relates activated T cell responses to patient risk factors and outcome. However, T cell response trajectory over the disease course remains an open question. Twit Text FOAVip Are T cells helpful for COVID-19: the relationship between response and risk ????J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=32976117 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32976117 #FOAvip English Wikipedia <ref>{{Cite pmid|32976117}}</ref> Are T cells helpful for COVID-19: the relationship between response and risk #MMPMID32976117 Griffin DE J Clin Invest 2020[Dec]; 130 (12): 6222-6224 PMID32976117show ga The disease spectrum of coronavirus disease 2019 (COVID-19) ranges from no symptoms to multisystem failure and death. Characterization of virus-specific immune responses to severe acute respiratory coronavirus 2 (SARS-CoV-2) is key to understanding disease pathogenesis, but few studies have evaluated T cell immunity. In this issue of the JCI, Sattler and Angermair et al. sampled blood from subjects with COVID-19 and analyzed the activation and function of virus antigen-specific CD4+ T cells. T cells that failed to respond to peptides from the membrane, spike, or nucleocapsid proteins were more common in subjects who died. In those whose T cells had the capacity to respond, older patients with comorbidity had larger numbers of activated T cells compared with patients who had fewer risk factors, but these cells showed impaired IFN-gamma production. This cross-sectional study relates activated T cell responses to patient risk factors and outcome. However, T cell response trajectory over the disease course remains an open question. |*Betacoronavirus[MESH] |*COVID-19[MESH] |*Pneumonia, Viral[MESH] |Cross-Sectional Studies[MESH] |Humans[MESH] |Pandemics[MESH] |SARS-CoV-2[MESH] |Spike Glycoprotein, Coronavirus[MESH]Are T cells helpful for COVID-19: the relationship between response an(epmc).pdf DeepDyve Pubget Overpricing