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10.1126/science.abe3354 http://scihub22266oqcxt.onion/10.1126/science.abe3354 32972994!7857395!32972994     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 2020 ; 370 (6519): 950-957 Nephropedia Template TP {{tp|p=32972994|t=2020. Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms |pdf=|usr=}}{{32972994}} gab.com Text Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=32972994 #FOAvip Efficient therapeutic options are needed to control the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that has caused more than 922,000 fatalities as of 13 September 2020. We report the isolation and characterization of two ultrapotent SARS-CoV-2 human neutralizing antibodies (S2E12 and S2M11) that protect hamsters against SARS-CoV-2 challenge. Cryo-electron microscopy structures show that S2E12 and S2M11 competitively block angiotensin-converting enzyme 2 (ACE2) attachment and that S2M11 also locks the spike in a closed conformation by recognition of a quaternary epitope spanning two adjacent receptor-binding domains. Antibody cocktails that include S2M11, S2E12, or the previously identified S309 antibody broadly neutralize a panel of circulating SARS-CoV-2 isolates and activate effector functions. Our results pave the way to implement antibody cocktails for prophylaxis or therapy, circumventing or limiting the emergence of viral escape mutants. Twit Text FOAVip Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms ????Science http://www.kidney.de/pget.php?&tw=1&pmid=32972994 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32972994 #FOAvip English Wikipedia <ref>{{Cite pmid|32972994}}</ref> Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms #MMPMID32972994 Tortorici MA; Beltramello M; Lempp FA; Pinto D; Dang HV; Rosen LE; McCallum M; Bowen J; Minola A; Jaconi S; Zatta F; De Marco A; Guarino B; Bianchi S; Lauron EJ; Tucker H; Zhou J; Peter A; Havenar-Daughton C; Wojcechowskyj JA; Case JB; Chen RE; Kaiser H; Montiel-Ruiz M; Meury M; Czudnochowski N; Spreafico R; Dillen J; Ng C; Sprugasci N; Culap K; Benigni F; Abdelnabi R; Foo SC; Schmid MA; Cameroni E; Riva A; Gabrieli A; Galli M; Pizzuto MS; Neyts J; Diamond MS; Virgin HW; Snell G; Corti D; Fink K; Veesler D Science 2020[Nov]; 370 (6519): 950-957 PMID32972994show ga Efficient therapeutic options are needed to control the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that has caused more than 922,000 fatalities as of 13 September 2020. We report the isolation and characterization of two ultrapotent SARS-CoV-2 human neutralizing antibodies (S2E12 and S2M11) that protect hamsters against SARS-CoV-2 challenge. Cryo-electron microscopy structures show that S2E12 and S2M11 competitively block angiotensin-converting enzyme 2 (ACE2) attachment and that S2M11 also locks the spike in a closed conformation by recognition of a quaternary epitope spanning two adjacent receptor-binding domains. Antibody cocktails that include S2M11, S2E12, or the previously identified S309 antibody broadly neutralize a panel of circulating SARS-CoV-2 isolates and activate effector functions. Our results pave the way to implement antibody cocktails for prophylaxis or therapy, circumventing or limiting the emergence of viral escape mutants. |Amino Acid Motifs/immunology[MESH] |Angiotensin-Converting Enzyme 2[MESH] |Animals[MESH] |Antibodies, Neutralizing/administration & dosage/*immunology/isolation & purification[MESH] |Antibodies, Viral/administration & dosage/*immunology/isolation & purification[MESH] |Betacoronavirus/*immunology[MESH] |CHO Cells[MESH] |COVID-19[MESH] |Coronavirus Infections/*prevention & control/therapy[MESH] |Cricetinae[MESH] |Cricetulus[MESH] |Cryoelectron Microscopy[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Immunodominant Epitopes/chemistry/immunology[MESH] |Microscopy, Electron[MESH] |Pandemics/*prevention & control[MESH] |Peptidyl-Dipeptidase A/*immunology[MESH] |Pneumonia, Viral/*prevention & control/therapy[MESH] |Protein Domains/immunology[MESH] |SARS-CoV-2[MESH]Ultrapotent human antibodies protect against SARS-CoV-2 challenge via (epmc).pdf DeepDyve Pubget Overpricing