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10.3390/ijms21186966 http://scihub22266oqcxt.onion/10.3390/ijms21186966 32971931!7554897!32971931     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32971931&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Int+J+Mol+Sci 2020 ; 21 (18): ? Nephropedia Template TP {{tp|p=32971931|t=2020. IL-21 in Homeostasis of Resident Memory and Exhausted CD8 T Cells during Persistent Infection |pdf=|usr=}}{{32971931}} gab.com Text IL-21 in Homeostasis of Resident Memory and Exhausted CD8 T Cells during Persistent Infection JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=32971931 #FOAvip CD4 T cells guide the development of CD8 T cells into memory by elaborating mitogenic and differentiation factors and by licensing professional antigen-presenting cells. CD4 T cells also act to stave off CD8 T cell dysfunction during repetitive antigen stimulation in persistent infection and cancer by mitigating generation of exhausted T cells (T(EX)). CD4 T cell help is also required for establishing and maintaining tissue-resident memory T cells (T(RM)), the nonrecirculating memory T cell subset parked in nonlymphoid tissues to provide frontline defense against reinvading pathogens. Interleukin (IL)-21 is the signature cytokine secreted by follicular helper CD4 T cells (T(FH)) to drive B cell expansion and differentiation in germinal centers to mount high-affinity, isotype class-switched antibodies. In several infection models, IL-21 has been identified as the CD4 T help needed for formation and survival of T(RM) and T(EX). In this review, we will explore the different memory subsets of CD8 T cells in persistent infections, the metabolic profiles associated with each, and evidence documenting the importance of CD4 T cell-derived IL-21 in regulating CD8 T(RM) and T(EX) development, homeostasis, and function. Twit Text FOAVip IL-21 in Homeostasis of Resident Memory and Exhausted CD8 T Cells during Persistent Infection ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=32971931 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32971931 #FOAvip English Wikipedia <ref>{{Cite pmid|32971931}}</ref> IL-21 in Homeostasis of Resident Memory and Exhausted CD8 T Cells during Persistent Infection #MMPMID32971931 Ren HM; Lukacher AE Int J Mol Sci 2020[Sep]; 21 (18): ? PMID32971931show ga CD4 T cells guide the development of CD8 T cells into memory by elaborating mitogenic and differentiation factors and by licensing professional antigen-presenting cells. CD4 T cells also act to stave off CD8 T cell dysfunction during repetitive antigen stimulation in persistent infection and cancer by mitigating generation of exhausted T cells (T(EX)). CD4 T cell help is also required for establishing and maintaining tissue-resident memory T cells (T(RM)), the nonrecirculating memory T cell subset parked in nonlymphoid tissues to provide frontline defense against reinvading pathogens. Interleukin (IL)-21 is the signature cytokine secreted by follicular helper CD4 T cells (T(FH)) to drive B cell expansion and differentiation in germinal centers to mount high-affinity, isotype class-switched antibodies. In several infection models, IL-21 has been identified as the CD4 T help needed for formation and survival of T(RM) and T(EX). In this review, we will explore the different memory subsets of CD8 T cells in persistent infections, the metabolic profiles associated with each, and evidence documenting the importance of CD4 T cell-derived IL-21 in regulating CD8 T(RM) and T(EX) development, homeostasis, and function. |*Immunologic Memory[MESH] |Animals[MESH] |B-Lymphocytes/immunology/pathology[MESH] |CD8-Positive T-Lymphocytes/*immunology/pathology[MESH] |Humans[MESH] |Immunoglobulin Class Switching/immunology[MESH] |Infections/*immunology/pathology[MESH] |Interleukin-21[MESH] |Interleukins/*immunology[MESH]IL-21 in Homeostasis of Resident Memory and Exhausted CD8 T Cells duri(epmc).pdf DeepDyve Pubget Overpricing