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10.1016/j.cbi.2020.109226 http://scihub22266oqcxt.onion/10.1016/j.cbi.2020.109226 32971122!7505113!32971122     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Chem+Biol+Interact 2020 ; 331 (ä): 109226 Nephropedia Template TP {{tp|p=32971122|t=2020. Deciphering the SSR incidences across viral members of Coronaviridae family |pdf=|usr=}}{{32971122}} gab.com Text Deciphering the SSR incidences across viral members of Coronaviridae family JO: Chem Biol Interact http://www.kidney.de/pget.php?&tw=1&pmid=32971122 #FOAvip Presence of Simple Sequence Repeats (SSRs), both in genic and intergenic regions, have been widely studied in eukaryotes, prokaryotes, and viruses. In the current study, we undertook a survey to analyze the frequency and distribution of microsatellites or SSRs in multiple genomes of Coronaviridae members. We successfully identified 919 SSRs with length >/=12 bp across 55 reference genomes majority of which (838 SSRs) were found abundant in genic regions. The in-silico analysis further identified the preferential abundance of hexameric SSRs than any other size-based motif class. Our analysis shows that the genome size and GC content of the genome had a weak influence on SSR frequency and density. However, we find a positive correlation of SSRs GC content with genomic GC content. We also report relatively low abundances of all theoretically possible 501 repeat motif classes in all the genomes of Coronaviridae. The majority of SSRs were AT-rich. Overall, we see an underrepresentation of SSRs across the genomes of Coronaviridae. Besides, our integrative study highlights the presence of SSRs in ORF1ab (nsp3, nsp4, nsp5A_3CLpro and nsp5B_3CLpro, nsp6, nsp10, nsp12, nsp13, & nsp15 domains), S, ORF3a, ORF7a, N & 3' UTR regions of SARS-CoV-2 and harbours multiple mutations (3'UTR and ORF1ab SSRs serving as major mutational hotspots). This indicates the genic SSRs are under selection pressure against mutations that might alter the reading frame and at the same time responsible for rapid protein evolution. Our preliminary results indicate the significance of the limited repertoire of SSRs in the genomes of Coronaviridae. Twit Text FOAVip Deciphering the SSR incidences across viral members of Coronaviridae family ????Chem Biol Interact http://www.kidney.de/pget.php?&tw=1&pmid=32971122 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32971122 #FOAvip English Wikipedia <ref>{{Cite pmid|32971122}}</ref> Deciphering the SSR incidences across viral members of Coronaviridae family #MMPMID32971122 Satyam R; Jha NK; Kar R; Jha SK; Sharma A; Kumar D; Nand P; Ruokolainen J; Kesari KK; Kamal MA Chem Biol Interact 2020[Nov]; 331 (ä): 109226 PMID32971122show ga Presence of Simple Sequence Repeats (SSRs), both in genic and intergenic regions, have been widely studied in eukaryotes, prokaryotes, and viruses. In the current study, we undertook a survey to analyze the frequency and distribution of microsatellites or SSRs in multiple genomes of Coronaviridae members. We successfully identified 919 SSRs with length >/=12 bp across 55 reference genomes majority of which (838 SSRs) were found abundant in genic regions. The in-silico analysis further identified the preferential abundance of hexameric SSRs than any other size-based motif class. Our analysis shows that the genome size and GC content of the genome had a weak influence on SSR frequency and density. However, we find a positive correlation of SSRs GC content with genomic GC content. We also report relatively low abundances of all theoretically possible 501 repeat motif classes in all the genomes of Coronaviridae. The majority of SSRs were AT-rich. Overall, we see an underrepresentation of SSRs across the genomes of Coronaviridae. Besides, our integrative study highlights the presence of SSRs in ORF1ab (nsp3, nsp4, nsp5A_3CLpro and nsp5B_3CLpro, nsp6, nsp10, nsp12, nsp13, & nsp15 domains), S, ORF3a, ORF7a, N & 3' UTR regions of SARS-CoV-2 and harbours multiple mutations (3'UTR and ORF1ab SSRs serving as major mutational hotspots). This indicates the genic SSRs are under selection pressure against mutations that might alter the reading frame and at the same time responsible for rapid protein evolution. Our preliminary results indicate the significance of the limited repertoire of SSRs in the genomes of Coronaviridae. |3' Untranslated Regions[MESH] |Base Composition[MESH] |Base Sequence[MESH] |Betacoronavirus/genetics[MESH] |Coronaviridae/*genetics[MESH] |Evolution, Molecular[MESH] |Genome, Viral[MESH] |Humans[MESH] |Microsatellite Repeats/*genetics[MESH] |Mutation[MESH] |Polyproteins[MESH] |SARS-CoV-2[MESH]Deciphering the SSR incidences across viral members of Coronaviridae f(epmc).pdf DeepDyve Pubget Overpricing