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10.1111/his.14257

http://scihub22266oqcxt.onion/10.1111/his.14257
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32970870!7537171!32970870
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suck abstract from ncbi


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pmid32970870      Histopathology 2021 ; 78 (4): 586-592
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  • Liquid-based cytological and immunohistochemical study of nasopharyngeal swab from persons under investigation for SARS-CoV-2 infection #MMPMID32970870
  • Parada D; Pena KB; Guma J; Guilarte C; Riu F
  • Histopathology 2021[Mar]; 78 (4): 586-592 PMID32970870show ga
  • INTRODUCTION: We describe cytologic and immunohistologic findings in virus transport medium on cases under investigation of SARS-CoV-2 infection. METHODS: Cytologic findings in cases under investigation of SARS-CoV-2 infection from one hundred consecutive nasopharyngeal swab were reviewed. Immunohistochemistry and SARSCoV-2 RT-PCR determination were performed to detect virus. RESULTS: No viral inclusions were noted in squamous cells obtained from virus transport medium. Immunohistochemical study with monoclonal antibody against SARS-CoV-2 viral nucleoprotein showed positivity in squamous cells. No positivity was present in others cellular components. CONCLUSIONS: SARS-CoV-2 predominantly localizes squamous cells in cytology samples of patients with RT-PCR positive determination of SARSCoV-2. The results of the current study support the notion that the nasopharyngeal region is the anatomical station that SARS-CoV-2 infects first, and the infection can lead to the migration of the virus into the lower airways.
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |COVID-19/*diagnosis/virology[MESH]
  • |Cytological Techniques[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Immunohistochemistry[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Nasopharynx/virology[MESH]


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