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10.1080/22221751.2020.1827985 http://scihub22266oqcxt.onion/10.1080/22221751.2020.1827985 32969768!7580600!32969768     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Emerg+Microbes+Infect 2020 ; 9 (1): 2169-2179 Nephropedia Template TP {{tp|p=32969768|t=2020. Robust and persistent SARS-CoV-2 infection in the human intestinal brush border expressing cells |pdf=|usr=}}{{32969768}} gab.com Text Robust and persistent SARS-CoV-2 infection in the human intestinal brush border expressing cells JO: Emerg Microbes Infect http://www.kidney.de/pget.php?&tw=1&pmid=32969768 #FOAvip Studies on patients with the coronavirus disease-2019 (COVID-19) have implicated that the gastrointestinal (GI) tract is a major site of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We established a human GI tract cell line model highly permissive to SARS-CoV-2. These cells, C2BBe1 intestinal cells with a brush border having high levels of transmembrane serine protease 2 (TMPRSS2), showed robust viral propagation, and could be persistently infected with SARS-CoV-2, supporting the clinical observations of persistent GI infection in COVID-19 patients. Ectopic expression of viral receptors revealed that the levels of angiotensin-converting enzyme 2 (ACE2) expression confer permissiveness to SARS-CoV-2 infection, and TMPRSS2 greatly facilitates ACE2-mediated SARS-CoV-2 dissemination. Interestingly, ACE2 but not TMPRSS2 expression was significantly promoted by enterocytic differentiation, suggesting that the state of enterocytic differentiation may serve as a determining factor for viral propagation. Thus, our study sheds light on the pathogenesis of SARS-CoV-2 in the GI tract. Twit Text FOAVip Robust and persistent SARS-CoV-2 infection in the human intestinal brush border expressing cells ????Emerg Microbes Infect http://www.kidney.de/pget.php?&tw=1&pmid=32969768 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32969768 #FOAvip English Wikipedia <ref>{{Cite pmid|32969768}}</ref> Robust and persistent SARS-CoV-2 infection in the human intestinal brush border expressing cells #MMPMID32969768 Lee S; Yoon GY; Myoung J; Kim SJ; Ahn DG Emerg Microbes Infect 2020[Dec]; 9 (1): 2169-2179 PMID32969768show ga Studies on patients with the coronavirus disease-2019 (COVID-19) have implicated that the gastrointestinal (GI) tract is a major site of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We established a human GI tract cell line model highly permissive to SARS-CoV-2. These cells, C2BBe1 intestinal cells with a brush border having high levels of transmembrane serine protease 2 (TMPRSS2), showed robust viral propagation, and could be persistently infected with SARS-CoV-2, supporting the clinical observations of persistent GI infection in COVID-19 patients. Ectopic expression of viral receptors revealed that the levels of angiotensin-converting enzyme 2 (ACE2) expression confer permissiveness to SARS-CoV-2 infection, and TMPRSS2 greatly facilitates ACE2-mediated SARS-CoV-2 dissemination. Interestingly, ACE2 but not TMPRSS2 expression was significantly promoted by enterocytic differentiation, suggesting that the state of enterocytic differentiation may serve as a determining factor for viral propagation. Thus, our study sheds light on the pathogenesis of SARS-CoV-2 in the GI tract. |Angiotensin-Converting Enzyme 2[MESH] |Betacoronavirus/genetics/*physiology[MESH] |COVID-19[MESH] |Cell Line[MESH] |Coronavirus Infections/genetics/metabolism/*virology[MESH] |Gastrointestinal Tract/metabolism/virology[MESH] |Humans[MESH] |Intestinal Mucosa/metabolism/*virology[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/genetics/metabolism[MESH] |Pneumonia, Viral/genetics/metabolism/*virology[MESH] |Receptors, Virus/genetics/metabolism[MESH] |SARS-CoV-2[MESH]Robust and persistent SARS-CoV-2 infection in the human intestinal bru(epmc).pdf DeepDyve Pubget Overpricing