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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Cancers+(Basel) 2020 ; 12 (9): ä Nephropedia Template TP
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Applications of Genome-Wide Screening and Systems Biology Approaches in Drug Repositioning #MMPMID32967266
Mohammadi E; Benfeitas R; Turkez H; Boren J; Nielsen J; Uhlen M; Mardinoglu A
Cancers (Basel) 2020[Sep]; 12 (9): ä PMID32967266show ga
Modern drug discovery through de novo drug discovery entails high financial costs, low success rates, and lengthy trial periods. Drug repositioning presents a suitable approach for overcoming these issues by re-evaluating biological targets and modes of action of approved drugs. Coupling high-throughput technologies with genome-wide essentiality screens, network analysis, genome-scale metabolic modeling, and machine learning techniques enables the proposal of new drug-target signatures and uncovers unanticipated modes of action for available drugs. Here, we discuss the current issues associated with drug repositioning in light of curated high-throughput multi-omic databases, genome-wide screening technologies, and their application in systems biology/medicine approaches.