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10.3390/v12091051

http://scihub22266oqcxt.onion/10.3390/v12091051
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32967229!7551039!32967229
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suck abstract from ncbi

pmid32967229      Viruses 2020 ; 12 (9): ä
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  • Immune Checkpoints in Viral Infections #MMPMID32967229
  • Cai H; Liu G; Zhong J; Zheng K; Xiao H; Li C; Song X; Li Y; Xu C; Wu H; He Z; Zhu Q
  • Viruses 2020[Sep]; 12 (9): ä PMID32967229show ga
  • As evidence has mounted that virus-infected cells, such as cancer cells, negatively regulate the function of T-cells via immune checkpoints, it has become increasingly clear that viral infections similarly exploit immune checkpoints as an immune system escape mechanism. Although immune checkpoint therapy has been successfully used in cancer treatment, numerous studies have suggested that such therapy may also be highly relevant for treating viral infection, especially chronic viral infections. However, it has not yet been applied in this manner. Here, we reviewed recent findings regarding immune checkpoints in viral infections, including COVID-19, and discussed the role of immune checkpoints in different viral infections, as well as the potential for applying immune checkpoint blockades as antiviral therapy.
  • |Animals[MESH]
  • |Antiviral Agents/therapeutic use[MESH]
  • |Chronic Disease[MESH]
  • |Humans[MESH]
  • |Immunologic Factors/antagonists & inhibitors/*immunology[MESH]
  • |Immunotherapy[MESH]
  • |Lymphocyte Activation/drug effects[MESH]
  • |T-Lymphocytes/immunology/pathology[MESH]
  • |Virus Diseases/*immunology/therapy[MESH]


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