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10.1016/j.celrep.2020.108199 http://scihub22266oqcxt.onion/10.1016/j.celrep.2020.108199 32966801!7474886!32966801     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2020 ; 32 (13): 108199 Nephropedia Template TP {{tp|p=32966801|t=2020. Activation of the SARS-CoV-2 Receptor Ace2 through JAK/STAT-Dependent Enhancers during Pregnancy |pdf=|usr=}}{{32966801}} gab.com Text Activation of the SARS-CoV-2 Receptor Ace2 through JAK/STAT-Dependent Enhancers during Pregnancy JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=32966801 #FOAvip ACE2 binds the coronavirus SARS-CoV-2 and facilitates its cellular entry. Interferons activate ACE2 expression in pneumocytes, suggesting a critical role of cytokines in SARS-CoV-2 target cells. Viral RNA was detected in breast milk in at least seven studies, raising the possibility that ACE2 is expressed in mammary tissue during lactation. Here, we show that Ace2 expression in mouse mammary tissue is induced during pregnancy and lactation, which coincides with the activation of intronic enhancers. These enhancers are occupied by the prolactin-activated transcription factor STAT5 and additional regulatory factors, including RNA polymerase II. Deletion of Stat5a results in decommissioning of the enhancers and an 83% reduction of Ace2 mRNA. We also demonstrate that Ace2 expression increases during lactation in lung, but not in kidney and intestine. JAK/STAT components are present in a range of SARS-CoV-2 target cells, opening the possibility that cytokines contribute to the viral load and extrapulmonary pathophysiology. Twit Text FOAVip Activation of the SARS-CoV-2 Receptor Ace2 through JAK/STAT-Dependent Enhancers during Pregnancy ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=32966801 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32966801 #FOAvip English Wikipedia <ref>{{Cite pmid|32966801}}</ref> Activation of the SARS-CoV-2 Receptor Ace2 through JAK/STAT-Dependent Enhancers during Pregnancy #MMPMID32966801 Hennighausen L; Lee HK Cell Rep 2020[Sep]; 32 (13): 108199 PMID32966801show ga ACE2 binds the coronavirus SARS-CoV-2 and facilitates its cellular entry. Interferons activate ACE2 expression in pneumocytes, suggesting a critical role of cytokines in SARS-CoV-2 target cells. Viral RNA was detected in breast milk in at least seven studies, raising the possibility that ACE2 is expressed in mammary tissue during lactation. Here, we show that Ace2 expression in mouse mammary tissue is induced during pregnancy and lactation, which coincides with the activation of intronic enhancers. These enhancers are occupied by the prolactin-activated transcription factor STAT5 and additional regulatory factors, including RNA polymerase II. Deletion of Stat5a results in decommissioning of the enhancers and an 83% reduction of Ace2 mRNA. We also demonstrate that Ace2 expression increases during lactation in lung, but not in kidney and intestine. JAK/STAT components are present in a range of SARS-CoV-2 target cells, opening the possibility that cytokines contribute to the viral load and extrapulmonary pathophysiology. |Angiotensin-Converting Enzyme 2[MESH] |Animals[MESH] |Enhancer Elements, Genetic[MESH] |Female[MESH] |Humans[MESH] |Intestinal Mucosa/metabolism[MESH] |Janus Kinases/*metabolism[MESH] |Kidney/metabolism[MESH] |Lactation/metabolism[MESH] |Lung/metabolism[MESH] |Mammary Glands, Human/metabolism[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |Peptidyl-Dipeptidase A/genetics/*metabolism[MESH] |Pregnancy/*metabolism[MESH] |STAT5 Transcription Factor/genetics/*metabolism[MESH]Activation of the SARS-CoV-2 Receptor Ace2 through JAK/STAT-Dependent (epmc).pdf DeepDyve Pubget Overpricing