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10.1002/rmv.2162

http://scihub22266oqcxt.onion/10.1002/rmv.2162
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suck abstract from ncbi


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pmid32964627      Rev+Med+Virol 2021 ; 31 (2): e2162
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  • Immune response following infection with SARS-CoV-2 and other coronaviruses: A rapid review #MMPMID32964627
  • O Murchu E; Byrne P; Walsh KA; Carty PG; Connolly M; De Gascun C; Jordan K; Keoghan M; O'Brien KK; O'Neill M; Smith SM; Teljeur C; Ryan M; Harrington P
  • Rev Med Virol 2021[Mar]; 31 (2): e2162 PMID32964627show ga
  • In this review, we systematically searched and summarized the evidence on the immune response and reinfection rate following SARS-CoV-2 infection. We also retrieved studies on SARS-CoV and MERS-CoV to assess the long-term duration of antibody responses. A protocol based on Cochrane rapid review methodology was adhered to and databases were searched from 1/1/2000 until 26/5/2020. Of 4744 citations retrieved, 102 studies met our inclusion criteria. Seventy-four studies were retrieved on SARS-CoV-2. While the rate and timing of IgM and IgG seroconversion were inconsistent across studies, most seroconverted for IgG within 2 weeks and 100% (N = 62) within 4 weeks. IgG was still detected at the end of follow-up (49-65 days) in all patients (N = 24). Neutralizing antibodies were detected in 92%-100% of patients (up to 53 days). It is not clear if reinfection with SARS-CoV-2 is possible, with studies more suggestive of intermittent detection of residual RNA. Twenty-five studies were retrieved on SARS-CoV. In general, SARS-CoV-specific IgG was maintained for 1-2 years post-infection and declined thereafter, although one study detected IgG up to 12 years post-infection. Neutralizing antibodies were detected up to 17 years in another study. Three studies on MERS-CoV reported that IgG may be detected up to 2 years. In conclusion, limited early data suggest that most patients seroconvert for SARS-CoV-2-specific IgG within 2 weeks. While the long-term duration of antibody responses is unknown, evidence from SARS-CoV studies suggest SARS-CoV-specific IgG is sustained for 1-2 years and declines thereafter.
  • |Antibodies, Neutralizing/immunology[MESH]
  • |Antibodies, Viral/immunology[MESH]
  • |COVID-19/*immunology[MESH]
  • |Coronavirus Infections/*immunology[MESH]
  • |Coronavirus/*immunology[MESH]
  • |Humans[MESH]
  • |Immunity/*immunology[MESH]
  • |Immunoglobulin G/immunology[MESH]
  • |Immunoglobulin M/immunology[MESH]


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