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10.1111/echo.14869

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suck abstract from ncbi


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pmid32964483      Echocardiography 2020 ; 37 (12): 2029-2039
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  • Prognostic utility of quantitative offline 2D-echocardiography in hospitalized patients with COVID-19 disease #MMPMID32964483
  • Bursi F; Santangelo G; Sansalone D; Valli F; Vella AM; Toriello F; Barbieri A; Carugo S
  • Echocardiography 2020[Dec]; 37 (12): 2029-2039 PMID32964483show ga
  • PURPOSE: To assess the prognostic utility of quantitative 2D-echocardiography, including strain, in patients with COVID-19 disease. METHODS: COVID-19-infected patients admitted to the San Paolo University Hospital of Milan that underwent a clinically indicated echocardiographic examination were included in the study. To limit contamination, all measurements were performed offline. Quantitative measurements were obtained by an operator blinded to the clinical data. RESULTS: Among the 49 patients, nonsurvivors (33%) had worse respiratory parameters, index of multiorgan failure, and worse markers of lung involvement. Right ventricular (RV) dysfunction (as assessed by conventional and 2-dimensional speckle tracking) was a common finding and a powerful independent predictor of mortality. At the ROC curve analyses, RV free wall longitudinal strain (LS) showed an AUC 0.77 +/- 0.08 in predicting death, P = .008, and global RV LS (RV-GLS) showed an AUC 0.79 +/- 0.04, P = .004. This association remained significant after correction for age (OR = 1.16, 95%CI 1.01-1.34, P = .029 for RV free wall LS and OR = 1.20, 95%CI 1.01-1.42, P = .033 for RV-GLS), for oxygen partial pressure at arterial gas analysis/fraction of inspired oxygen (OR = 1.28, 95%CI 1.04-1.57, P = .021 for RV free wall-LS and OR = 1.30, 95%CI 1.04-1.62, P = .020 for RV-GLS) and for the severity of pulmonary involvement measured by a computed tomography lung score (OR = 1.27, 95%CI 1.02-1.19, P = .034 for RV free wall LS and OR = 1.30, 95%CI 1.04-1.63, P = .022 for RV-GLS). CONCLUSIONS: In patients hospitalized with COVID-19, offline quantitative 2D-echocardiographic assessment of cardiac function is feasible. Parameters of RV function are frequently abnormal and have an independent prognostic value over markers of lung involvement.
  • |*Echocardiography[MESH]
  • |Aged[MESH]
  • |Biomarkers/blood[MESH]
  • |COVID-19/*diagnostic imaging[MESH]
  • |Female[MESH]
  • |Hospitalization[MESH]
  • |Humans[MESH]
  • |Italy[MESH]
  • |Male[MESH]
  • |Pneumonia, Viral/*diagnostic imaging/virology[MESH]
  • |Prognosis[MESH]
  • |Retrospective Studies[MESH]
  • |SARS-CoV-2[MESH]
  • |Severity of Illness Index[MESH]
  • |Tomography, X-Ray Computed[MESH]


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