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10.1155/2020/5630838

http://scihub22266oqcxt.onion/10.1155/2020/5630838
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32963564!7499281!32963564
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suck abstract from ncbi

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  • Tea Polyphenols EGCG and Theaflavin Inhibit the Activity of SARS-CoV-2 3CL-Protease In Vitro #MMPMID32963564
  • Jang M; Park YI; Cha YE; Park R; Namkoong S; Lee JI; Park J
  • Evid Based Complement Alternat Med 2020[]; 2020 (ä): 5630838 PMID32963564show ga
  • COVID-19, a global pandemic, has caused over 750,000 deaths worldwide as of August 2020. A vaccine or remedy for SARS-CoV-2, the virus responsible for COVID-19, is necessary to slow down the spread and lethality of COVID-19. However, there is currently no effective treatment available against SARS-CoV-2. In this report, we demonstrated that EGCG and theaflavin, the main active ingredients of green tea and black tea, respectively, are potentially effective to inhibit SARS-CoV-2 activity. Coronaviruses require the 3CL-protease for the cleavage of its polyprotein to make individual proteins functional. EGCG and theaflavin showed inhibitory activity against the SARS-CoV-2 3CL-protease in a dose-dependent manner, and the half inhibitory concentration (IC50) was 7.58 mug/ml for EGCG and 8.44 mug/ml for theaflavin. In addition, we did not observe any cytotoxicity for either EGCG or theaflavin at the concentrations tested up to 40 mug/ml in HEK293T cells. These results suggest that upon further study, EGCG and theaflavin can be potentially useful to treat COVID-19.
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  • suck abstract from ncbi

    5630838 ä.2020 2020