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10.2169/internalmedicine.5244-20

http://scihub22266oqcxt.onion/10.2169/internalmedicine.5244-20
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32963155!7725631!32963155
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suck abstract from ncbi


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pmid32963155      Intern+Med 2020 ; 59 (22): 2945-2949
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  • Acute Hypertriglyceridaemia Caused by Tocilizumab in a Patient with Severe COVID-19 #MMPMID32963155
  • Nakamura H; Miyagi K; Otsuki M; Higure Y; Nishiyama N; Kinjo T; Nakamatsu M; Haranaga S; Tateyama M; Fujita J
  • Intern Med 2020[Nov]; 59 (22): 2945-2949 PMID32963155show ga
  • Treatment with tocilizumab (TCZ) to block interleukin-6 (IL-6) signalling is predicted to mitigate cytokine release syndrome (CRS) caused by coronavirus disease 2019 (COVID-19). However, the adverse effects of TCZ on patients with COVID-19 remain unclear. We herein report a patient with COVID-19 treated with TCZ who developed acute hypertriglyceridaemia. Despite favipiravir treatment, acute respiratory distress syndrome developed in a 45-year-old patient with COVID-19; thus, TCZ was initiated. The triglyceride levels greatly increased after TCZ administration. Physicians should consider the negative impact of TCZ on the lipid profile in patients with COVID-19, although COVID-19-induced CRS itself may be an aggravating factor.
  • |*Betacoronavirus[MESH]
  • |Acute Disease[MESH]
  • |Antibodies, Monoclonal, Humanized/*adverse effects/therapeutic use[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/blood/*drug therapy/epidemiology[MESH]
  • |Humans[MESH]
  • |Hypertriglyceridemia/blood/*chemically induced[MESH]
  • |Interleukin-6/blood[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/blood/*drug therapy/epidemiology[MESH]
  • |Retrospective Studies[MESH]
  • |SARS-CoV-2[MESH]


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