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10.1016/j.arcmed.2020.09.013 http://scihub22266oqcxt.onion/10.1016/j.arcmed.2020.09.013 32962867!7498210!32962867     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Arch+Med+Res 2021 ; 52 (1): 38-47 Nephropedia Template TP {{tp|p=32962867|t=2021. Targeting SARS-CoV-2 Main Protease: A Computational Drug Repurposing Study |pdf=|usr=}}{{32962867}} gab.com Text Targeting SARS-CoV-2 Main Protease: A Computational Drug Repurposing Study JO: Arch Med Res http://www.kidney.de/pget.php?&tw=1&pmid=32962867 #FOAvip BACKGROUND AND AIMS: Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) induced Novel Coronavirus Disease (COVID-19) has currently become pandemic worldwide. Though drugs like remdesivir, favipiravir, and dexamethasone found beneficial for COVID-19 management, they have limitations clinically, and vaccine development takes a long time. The researchers have reported key proteins which could act as druggable targets. Among them, the major protease M(pro) is first published, plays a prominent role in viral replication and an attractive drug-target for drug discovery. Hence, to target M(pro) and inhibit it, we accomplished the virtual screening of US-FDA approved drugs using well-known drug repurposing approach by computer-aided tools. METHODS: The protein M(pro), PDB-ID 6LU7 was imported to Maestro graphical user interphase of Schrodinger software. The US-FDA approved drug structures are imported from DrugBank and docked after preliminary protein and ligand preparation. The drugs are shortlisted based on the docking scores in the Standard Precision method (SP-docking) and then based on the type of molecular interactions they are studied for molecular dynamics simulations. RESULTS: The docking and molecular interactions studies, five drugs emerged as potential hits by forming hydrophilic, hydrophobic, electrostatic interactions. The drugs such as arbutin, terbutaline, barnidipine, tipiracil and aprepitant identified as potential hits. Among the drugs, tipiracil and aprepitant interacted with the M(pro) consistently, and they turned out to be most promising. CONCLUSIONS: This study shows the possible exploration for drug repurposing using computer-aided docking tools and the potential roles of tipiracil and aprepitant, which can be explored further in the treatment of COVID-19. Twit Text FOAVip Targeting SARS-CoV-2 Main Protease: A Computational Drug Repurposing Study ????Arch Med Res http://www.kidney.de/pget.php?&tw=1&pmid=32962867 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32962867 #FOAvip English Wikipedia <ref>{{Cite pmid|32962867}}</ref> Targeting SARS-CoV-2 Main Protease: A Computational Drug Repurposing Study #MMPMID32962867 Baby K; Maity S; Mehta CH; Suresh A; Nayak UY; Nayak Y Arch Med Res 2021[Jan]; 52 (1): 38-47 PMID32962867show ga BACKGROUND AND AIMS: Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) induced Novel Coronavirus Disease (COVID-19) has currently become pandemic worldwide. Though drugs like remdesivir, favipiravir, and dexamethasone found beneficial for COVID-19 management, they have limitations clinically, and vaccine development takes a long time. The researchers have reported key proteins which could act as druggable targets. Among them, the major protease M(pro) is first published, plays a prominent role in viral replication and an attractive drug-target for drug discovery. Hence, to target M(pro) and inhibit it, we accomplished the virtual screening of US-FDA approved drugs using well-known drug repurposing approach by computer-aided tools. METHODS: The protein M(pro), PDB-ID 6LU7 was imported to Maestro graphical user interphase of Schrodinger software. The US-FDA approved drug structures are imported from DrugBank and docked after preliminary protein and ligand preparation. The drugs are shortlisted based on the docking scores in the Standard Precision method (SP-docking) and then based on the type of molecular interactions they are studied for molecular dynamics simulations. RESULTS: The docking and molecular interactions studies, five drugs emerged as potential hits by forming hydrophilic, hydrophobic, electrostatic interactions. The drugs such as arbutin, terbutaline, barnidipine, tipiracil and aprepitant identified as potential hits. Among the drugs, tipiracil and aprepitant interacted with the M(pro) consistently, and they turned out to be most promising. CONCLUSIONS: This study shows the possible exploration for drug repurposing using computer-aided docking tools and the potential roles of tipiracil and aprepitant, which can be explored further in the treatment of COVID-19. |*COVID-19 Drug Treatment[MESH] |Antiviral Agents/chemistry/pharmacology/*therapeutic use[MESH] |COVID-19/virology[MESH] |Coronavirus 3C Proteases/*antagonists & inhibitors/chemistry/metabolism[MESH] |Drug Discovery/methods[MESH] |Drug Repositioning/*methods[MESH] |Humans[MESH] |Molecular Docking Simulation/methods[MESH] |Molecular Dynamics Simulation[MESH] |Molecular Targeted Therapy[MESH] |Protease Inhibitors/chemistry/pharmacology/*therapeutic use[MESH]Targeting SARS-CoV-2 Main Protease: A Computational Drug Repurposing S(epmc).pdf DeepDyve Pubget Overpricing