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10.1186/s42358-020-00151-7 http://scihub22266oqcxt.onion/10.1186/s42358-020-00151-7 32962761!7506814!32962761     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Adv+Rheumatol 2020 ; 60 (1): 50 Nephropedia Template TP {{tp|p=32962761|t=2020. Severe COVID-19: what have we learned with the immunopathogenesis?|pdf=|usr=}}{{32962761}} gab.com Text Severe COVID-19: what have we learned with the immunopathogenesis JO: Adv Rheumatol http://www.kidney.de/pget.php?&tw=1&pmid=32962761 #FOAvip The COVID-19 outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global major concern. In this review, we addressed a theoretical model on immunopathogenesis associated with severe COVID-19, based on the current literature of SARS-CoV-2 and other epidemic pathogenic coronaviruses, such as SARS and MERS. Several studies have suggested that immune dysregulation and hyperinflammatory response induced by SARS-CoV-2 are more involved in disease severity than the virus itself.Immune dysregulation due to COVID-19 is characterized by delayed and impaired interferon response, lymphocyte exhaustion and cytokine storm that ultimately lead to diffuse lung tissue damage and posterior thrombotic phenomena.Considering there is a lack of clinical evidence provided by randomized clinical trials, the knowledge about SARS-CoV-2 disease pathogenesis and immune response is a cornerstone to develop rationale-based clinical therapeutic strategies. In this narrative review, the authors aimed to describe the immunopathogenesis of severe forms of COVID-19. Twit Text FOAVip Severe COVID-19: what have we learned with the immunopathogenesis ????Adv Rheumatol http://www.kidney.de/pget.php?&tw=1&pmid=32962761 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32962761 #FOAvip English Wikipedia <ref>{{Cite pmid|32962761}}</ref> Severe COVID-19: what have we learned with the immunopathogenesis? #MMPMID32962761 Bordallo B; Bellas M; Cortez AF; Vieira M; Pinheiro M Adv Rheumatol 2020[Sep]; 60 (1): 50 PMID32962761show ga The COVID-19 outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global major concern. In this review, we addressed a theoretical model on immunopathogenesis associated with severe COVID-19, based on the current literature of SARS-CoV-2 and other epidemic pathogenic coronaviruses, such as SARS and MERS. Several studies have suggested that immune dysregulation and hyperinflammatory response induced by SARS-CoV-2 are more involved in disease severity than the virus itself.Immune dysregulation due to COVID-19 is characterized by delayed and impaired interferon response, lymphocyte exhaustion and cytokine storm that ultimately lead to diffuse lung tissue damage and posterior thrombotic phenomena.Considering there is a lack of clinical evidence provided by randomized clinical trials, the knowledge about SARS-CoV-2 disease pathogenesis and immune response is a cornerstone to develop rationale-based clinical therapeutic strategies. In this narrative review, the authors aimed to describe the immunopathogenesis of severe forms of COVID-19. |Age Factors[MESH] |Angiotensin-Converting Enzyme 2[MESH] |Animals[MESH] |Antibody Formation[MESH] |Betacoronavirus/*immunology/pathogenicity[MESH] |Blood Coagulation Disorders/etiology[MESH] |COVID-19[MESH] |Comorbidity[MESH] |Coronavirus Infections/blood/complications/epidemiology/*immunology[MESH] |Cytokine Release Syndrome/*immunology[MESH] |Humans[MESH] |Immunity, Innate[MESH] |Inflammation/immunology[MESH] |Lung/pathology[MESH] |Lymphopenia/immunology[MESH] |Mice[MESH] |Middle East Respiratory Syndrome Coronavirus/immunology[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/physiology[MESH] |Pneumonia, Viral/blood/complications/epidemiology/*immunology[MESH] |Respiratory Distress Syndrome/*immunology[MESH] |Risk Factors[MESH] |SARS-CoV-2[MESH] |Severe Acute Respiratory Syndrome/immunology[MESH] |Severity of Illness Index[MESH] |Sex Factors[MESH]Severe COVID-19: what have we learned with the immunopathogenesis?(epmc).pdf DeepDyve Pubget Overpricing