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10.3906/sag-2008-32 http://scihub22266oqcxt.onion/10.3906/sag-2008-32 32962330!7672349!32962330     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32962330&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Turk+J+Med+Sci 2020 ; 50 (SI-2): 1655-1664 Nephropedia Template TP {{tp|p=32962330|t=2020. Physiological and pharmacological roles of melatonin in the pathophysiological components of cellular injury after ischemic stroke |pdf=|usr=}}{{32962330}} gab.com Text Physiological and pharmacological roles of melatonin in the pathophysiological components of cellular injury after ischemic stroke JO: Turk J Med Sci http://www.kidney.de/pget.php?&tw=1&pmid=32962330 #FOAvip Apart from its metabolic or physiological functions, melatonin has a potent cytoprotective activity in the physiological and pathological conditions. It is synthetized by the pineal gland and released into the blood circulation but particularly cerebrospinal fluid in a circadian manner. It can also easily diffuse through cellular membranes due its small size and lipophilic structure. Its cytoprotective activity has been linked to its potent free radical scavenger activity with the desirable characteristics of a clinically- reliable antioxidant. Melatonin detoxifies oxygen and nitrogen-based free radicals and oxidizing agents, including the highly toxic hydroxyl-and peroxynitrite radicals, initiating cellular damage. However, the cytoprotective activity of melatonin is complex and cannot be solely limited to its free radical scavenger activity. It regulates cellular signaling pathways through receptor- dependent and independent mechanisms. Most of these downstream molecules, such as PI3K/AKT pathway components, also contribute to the cytoprotective effects of melatonin. In this term, melatonin is a promising molecule for the treatment of neurodegenerative disorders, such as ischemic stroke, which melatonin reduces ischemic brain injury in animal models of ischemic stroke. It regulates also circadian rhythm proteins after ischemic stroke, playing roles in cellular survival. In this context, present article summarizes the possible role of melatonin in the pathophysiological events after ischemic stroke. Twit Text FOAVip Physiological and pharmacological roles of melatonin in the pathophysiological components of cellular injury after ischemic stroke ????Turk J Med Sci http://www.kidney.de/pget.php?&tw=1&pmid=32962330 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32962330 #FOAvip English Wikipedia <ref>{{Cite pmid|32962330}}</ref> Physiological and pharmacological roles of melatonin in the pathophysiological components of cellular injury after ischemic stroke #MMPMID32962330 Kilic E; Caglayan B; Caglar Beker M Turk J Med Sci 2020[Nov]; 50 (SI-2): 1655-1664 PMID32962330show ga Apart from its metabolic or physiological functions, melatonin has a potent cytoprotective activity in the physiological and pathological conditions. It is synthetized by the pineal gland and released into the blood circulation but particularly cerebrospinal fluid in a circadian manner. It can also easily diffuse through cellular membranes due its small size and lipophilic structure. Its cytoprotective activity has been linked to its potent free radical scavenger activity with the desirable characteristics of a clinically- reliable antioxidant. Melatonin detoxifies oxygen and nitrogen-based free radicals and oxidizing agents, including the highly toxic hydroxyl-and peroxynitrite radicals, initiating cellular damage. However, the cytoprotective activity of melatonin is complex and cannot be solely limited to its free radical scavenger activity. It regulates cellular signaling pathways through receptor- dependent and independent mechanisms. Most of these downstream molecules, such as PI3K/AKT pathway components, also contribute to the cytoprotective effects of melatonin. In this term, melatonin is a promising molecule for the treatment of neurodegenerative disorders, such as ischemic stroke, which melatonin reduces ischemic brain injury in animal models of ischemic stroke. It regulates also circadian rhythm proteins after ischemic stroke, playing roles in cellular survival. In this context, present article summarizes the possible role of melatonin in the pathophysiological events after ischemic stroke. |*Ischemic Stroke/metabolism/physiopathology[MESH] |*Melatonin/metabolism/pharmacology/physiology[MESH] |Animals[MESH] |Apoptosis/*drug effects[MESH] |Circadian Rhythm Signaling Peptides and Proteins/metabolism[MESH] |Free Radicals/metabolism[MESH] |Humans[MESH] |Mice[MESH] |Protective Agents/metabolism/pharmacology[MESH] |Rats[MESH]Physiological and pharmacological roles of melatonin in the pathophysi(epmc).pdf DeepDyve Pubget Overpricing