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Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Arterioscler+Thromb+Vasc+Biol 2020 ; 40 (11): 2586-2597 Nephropedia Template TP
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COVID-19 and Respiratory System Disorders: Current Knowledge, Future Clinical and Translational Research Questions #MMPMID32960072
Brosnahan SB; Jonkman AH; Kugler MC; Munger JS; Kaufman DA
Arterioscler Thromb Vasc Biol 2020[Nov]; 40 (11): 2586-2597 PMID32960072show ga
The severe acute respiratory syndrome coronavirus-2 emerged as a serious human pathogen in late 2019, causing the disease coronavirus disease 2019 (COVID-19). The most common clinical presentation of severe COVID-19 is acute respiratory failure consistent with the acute respiratory distress syndrome. Airway, lung parenchymal, pulmonary vascular, and respiratory neuromuscular disorders all feature in COVID-19. This article reviews what is known about the effects of severe acute respiratory syndrome coronavirus-2 infection on different parts of the respiratory system, clues to understanding the underlying biology of respiratory disease, and highlights current and future translation and clinical research questions.