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10.4049/jimmunol.2000892

http://scihub22266oqcxt.onion/10.4049/jimmunol.2000892
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32958687!ä!32958687

suck abstract from ncbi


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pmid32958687      J+Immunol 2020 ; 205 (10): 2566-2575
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  • Immune Response Resetting as a Novel Strategy to Overcome SARS-CoV-2-Induced Cytokine Storm #MMPMID32958687
  • Nowill AE; de Campos-Lima PO
  • J Immunol 2020[Nov]; 205 (10): 2566-2575 PMID32958687show ga
  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), which rapidly became a pandemic of global proportions. Sepsis is commonly present with high lethality in the severe forms of the disease. The virus-induced cytokine storm puts the immune system in overdrive at the expense of the pathogen-specific immune response and is likely to underlie the most advanced COVID-19 clinical features, including sepsis-related multiple organ dysfunction as well as the pathophysiological changes found in the lungs. We review the major therapeutic strategies that have been considered for sepsis and might be amenable to repurposing for COVID-19. We also discuss two different immunization strategies that have the potential to confer antiviral heterologous protection: innate-induced trained immunity and adaptive-induced immune response resetting.
  • |*Adaptive Immunity[MESH]
  • |*Coronavirus Infections/immunology/pathology/therapy[MESH]
  • |*Immunity, Innate[MESH]
  • |*Multiple Organ Failure/immunology/pathology/therapy[MESH]
  • |*Pandemics[MESH]
  • |*Pneumonia, Viral/immunology/pathology/therapy[MESH]
  • |Betacoronavirus/*immunology[MESH]
  • |COVID-19[MESH]
  • |Cytokines/*immunology[MESH]
  • |Humans[MESH]


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