Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1126/scitranslmed.abd5487 http://scihub22266oqcxt.onion/10.1126/scitranslmed.abd5487 32958614!7658796!32958614     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Transl+Med 2020 ; 12 (564): ä Nephropedia Template TP {{tp|p=32958614|t=2020. Immune responses to SARS-CoV-2 infection in hospitalized pediatric and adult patients |pdf=|usr=}}{{32958614}} gab.com Text Immune responses to SARS-CoV-2 infection in hospitalized pediatric and adult patients JO: Sci Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=32958614 #FOAvip Children and youth infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have milder disease than do adults, and even among those with the recently described multisystem inflammatory syndrome, mortality is rare. The reasons for the differences in clinical manifestations are unknown but suggest that age-dependent factors may modulate the antiviral immune response. We compared cytokine, humoral, and cellular immune responses in pediatric (children and youth, age <24 years) (n = 65) and adult (n = 60) patients with coronavirus disease 2019 (COVID-19) at a metropolitan hospital system in New York City. The pediatric patients had a shorter length of stay, decreased requirement for mechanical ventilation, and lower mortality compared to adults. The serum concentrations of interleukin-17A (IL-17A) and interferon-gamma (IFN-gamma), but not tumor necrosis factor-alpha (TNF-alpha) or IL-6, were inversely related to age. Adults mounted a more robust T cell response to the viral spike protein compared to pediatric patients as evidenced by increased expression of CD25(+) on CD4(+) T cells and the frequency of IFN-gamma(+) CD4(+) T cells. Moreover, serum neutralizing antibody titers and antibody-dependent cellular phagocytosis were higher in adults compared to pediatric patients with COVID-19. The neutralizing antibody titer correlated positively with age and negatively with IL-17A and IFN-gamma serum concentrations. There were no differences in anti-spike protein antibody titers to other human coronaviruses. Together, these findings demonstrate that the poor outcome in hospitalized adults with COVID-19 compared to children may not be attributable to a failure to generate adaptive immune responses. Twit Text FOAVip Immune responses to SARS-CoV-2 infection in hospitalized pediatric and adult patients ????Sci Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=32958614 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32958614 #FOAvip English Wikipedia <ref>{{Cite pmid|32958614}}</ref> Immune responses to SARS-CoV-2 infection in hospitalized pediatric and adult patients #MMPMID32958614 Pierce CA; Preston-Hurlburt P; Dai Y; Aschner CB; Cheshenko N; Galen B; Garforth SJ; Herrera NG; Jangra RK; Morano NC; Orner E; Sy S; Chandran K; Dziura J; Almo SC; Ring A; Keller MJ; Herold KC; Herold BC Sci Transl Med 2020[Oct]; 12 (564): ä PMID32958614show ga Children and youth infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have milder disease than do adults, and even among those with the recently described multisystem inflammatory syndrome, mortality is rare. The reasons for the differences in clinical manifestations are unknown but suggest that age-dependent factors may modulate the antiviral immune response. We compared cytokine, humoral, and cellular immune responses in pediatric (children and youth, age <24 years) (n = 65) and adult (n = 60) patients with coronavirus disease 2019 (COVID-19) at a metropolitan hospital system in New York City. The pediatric patients had a shorter length of stay, decreased requirement for mechanical ventilation, and lower mortality compared to adults. The serum concentrations of interleukin-17A (IL-17A) and interferon-gamma (IFN-gamma), but not tumor necrosis factor-alpha (TNF-alpha) or IL-6, were inversely related to age. Adults mounted a more robust T cell response to the viral spike protein compared to pediatric patients as evidenced by increased expression of CD25(+) on CD4(+) T cells and the frequency of IFN-gamma(+) CD4(+) T cells. Moreover, serum neutralizing antibody titers and antibody-dependent cellular phagocytosis were higher in adults compared to pediatric patients with COVID-19. The neutralizing antibody titer correlated positively with age and negatively with IL-17A and IFN-gamma serum concentrations. There were no differences in anti-spike protein antibody titers to other human coronaviruses. Together, these findings demonstrate that the poor outcome in hospitalized adults with COVID-19 compared to children may not be attributable to a failure to generate adaptive immune responses. |*Hospitalization[MESH] |Adolescent[MESH] |Adult[MESH] |Antibodies, Neutralizing/immunology[MESH] |Antibodies, Viral/blood[MESH] |Betacoronavirus/*physiology[MESH] |COVID-19[MESH] |Child[MESH] |Coronavirus Infections/blood/*immunology/*virology[MESH] |Cytokines/blood[MESH] |Female[MESH] |Humans[MESH] |Immunoglobulin G/metabolism[MESH] |Male[MESH] |Middle Aged[MESH] |Pandemics[MESH] |Pneumonia, Viral/blood/*immunology/*virology[MESH] |SARS-CoV-2[MESH] |Spike Glycoprotein, Coronavirus/metabolism[MESH]Immune responses to SARS-CoV-2 infection in hospitalized pediatric and(epmc).pdf DeepDyve Pubget Overpricing