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10.26508/lsa.202000883 http://scihub22266oqcxt.onion/10.26508/lsa.202000883 32958604!7536822!32958604     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Life+Sci+Alliance 2020 ; 3 (11): ä Nephropedia Template TP {{tp|p=32958604|t=2020. Implications for tetraspanin-enriched microdomain assembly based on structures of CD9 with EWI-F |pdf=|usr=}}{{32958604}} gab.com Text Implications for tetraspanin-enriched microdomain assembly based on structures of CD9 with EWI-F JO: Life Sci Alliance http://www.kidney.de/pget.php?&tw=1&pmid=32958604 #FOAvip Tetraspanins are eukaryotic membrane proteins that contribute to a variety of signaling processes by organizing partner-receptor molecules in the plasma membrane. How tetraspanins bind and cluster partner receptors into tetraspanin-enriched microdomains is unknown. Here, we present crystal structures of the large extracellular loop of CD9 bound to nanobodies 4C8 and 4E8 and, the cryo-EM structure of 4C8-bound CD9 in complex with its partner EWI-F. CD9-EWI-F displays a tetrameric arrangement with two central EWI-F molecules, dimerized through their ectodomains, and two CD9 molecules, one bound to each EWI-F transmembrane helix through CD9-helices h3 and h4. In the crystal structures, nanobodies 4C8 and 4E8 bind CD9 at loops C and D, which is in agreement with the 4C8 conformation in the CD9-EWI-F complex. The complex varies from nearly twofold symmetric (with the two CD9 copies nearly anti-parallel) to ca. 50 degrees bent arrangements. This flexible arrangement of CD9-EWI-F with potential CD9 homo-dimerization at either end provides a "concatenation model" for forming short linear or circular assemblies, which may explain the occurrence of tetraspanin-enriched microdomains. Twit Text FOAVip Implications for tetraspanin-enriched microdomain assembly based on structures of CD9 with EWI-F ????Life Sci Alliance http://www.kidney.de/pget.php?&tw=1&pmid=32958604 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32958604 #FOAvip English Wikipedia <ref>{{Cite pmid|32958604}}</ref> Implications for tetraspanin-enriched microdomain assembly based on structures of CD9 with EWI-F #MMPMID32958604 Oosterheert W; Xenaki KT; Neviani V; Pos W; Doulkeridou S; Manshande J; Pearce NM; Kroon-Batenburg LM; Lutz M; van Bergen En Henegouwen PM; Gros P Life Sci Alliance 2020[Nov]; 3 (11): ä PMID32958604show ga Tetraspanins are eukaryotic membrane proteins that contribute to a variety of signaling processes by organizing partner-receptor molecules in the plasma membrane. How tetraspanins bind and cluster partner receptors into tetraspanin-enriched microdomains is unknown. Here, we present crystal structures of the large extracellular loop of CD9 bound to nanobodies 4C8 and 4E8 and, the cryo-EM structure of 4C8-bound CD9 in complex with its partner EWI-F. CD9-EWI-F displays a tetrameric arrangement with two central EWI-F molecules, dimerized through their ectodomains, and two CD9 molecules, one bound to each EWI-F transmembrane helix through CD9-helices h3 and h4. In the crystal structures, nanobodies 4C8 and 4E8 bind CD9 at loops C and D, which is in agreement with the 4C8 conformation in the CD9-EWI-F complex. The complex varies from nearly twofold symmetric (with the two CD9 copies nearly anti-parallel) to ca. 50 degrees bent arrangements. This flexible arrangement of CD9-EWI-F with potential CD9 homo-dimerization at either end provides a "concatenation model" for forming short linear or circular assemblies, which may explain the occurrence of tetraspanin-enriched microdomains. |Antigens, CD/chemistry/metabolism/ultrastructure[MESH] |Carrier Proteins/metabolism[MESH] |Cell Line, Tumor[MESH] |Cell Membrane/metabolism[MESH] |Humans[MESH] |Membrane Glycoproteins/chemistry[MESH] |Membrane Proteins/chemistry/metabolism/ultrastructure[MESH] |Tetraspanin 28/metabolism/ultrastructure[MESH] |Tetraspanin 29/*metabolism/physiology/*ultrastructure[MESH] |Tetraspanins/metabolism/physiology/ultrastructure[MESH]Implications for tetraspanin-enriched microdomain assembly based on st(epmc).pdf DeepDyve Pubget Overpricing