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10.1016/j.lfs.2020.118469 http://scihub22266oqcxt.onion/10.1016/j.lfs.2020.118469 32956664!7499150!32956664     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Life+Sci 2020 ; 262 (ä): 118469 Nephropedia Template TP {{tp|p=32956664|t=2020. Assessment of effective imidazole derivatives against SARS-CoV-2 main protease through computational approach |pdf=|usr=}}{{32956664}} gab.com Text Assessment of effective imidazole derivatives against SARS-CoV-2 main protease through computational approach JO: Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=32956664 #FOAvip Because of the fast increase in deaths due to Corona Viral Infection in majority region in the world, the detection of drugs potent of this infection is a major need. With this idea, docking study was executed on eighteen imidazole derivatives based on 7-chloro-4-aminoquinoline against novel Coronavirus (SARS-CoV-2). In this study, we carried out a docking study of these molecules in the active site of SARS-CoV-2 main protease. The result indicate that Molecules N degrees 3, 7 and 14 have more binding energy with SARS-CoV-2 main protease recently crystallized (pdb code 6LU7) in comparison with the other imidazole derivatives and the two drug; Chloroquine and hydroxychloroquine. Because of the best energy of interaction, these three molecules could have the most potential antiviral treatment of COVID-19 than the other studied compounds. The structures with best affinity in the binding site of the protease have more than 3 cycles and electronegative atoms in the structure. This may increase the binding affinity of these molecules because of formation of pi-bonds, halogen interactions and/or Hydrogen bond interactions between compounds and the enzyme. So, compounds with more cycles and electronegative atoms could have a potent inhibition of SARS-CoV-2 main protease. Twit Text FOAVip Assessment of effective imidazole derivatives against SARS-CoV-2 main protease through computational approach ????Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=32956664 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32956664 #FOAvip English Wikipedia <ref>{{Cite pmid|32956664}}</ref> Assessment of effective imidazole derivatives against SARS-CoV-2 main protease through computational approach #MMPMID32956664 Belhassan A; En-Nahli F; Zaki H; Lakhlifi T; Bouachrine M Life Sci 2020[Dec]; 262 (ä): 118469 PMID32956664show ga Because of the fast increase in deaths due to Corona Viral Infection in majority region in the world, the detection of drugs potent of this infection is a major need. With this idea, docking study was executed on eighteen imidazole derivatives based on 7-chloro-4-aminoquinoline against novel Coronavirus (SARS-CoV-2). In this study, we carried out a docking study of these molecules in the active site of SARS-CoV-2 main protease. The result indicate that Molecules N degrees 3, 7 and 14 have more binding energy with SARS-CoV-2 main protease recently crystallized (pdb code 6LU7) in comparison with the other imidazole derivatives and the two drug; Chloroquine and hydroxychloroquine. Because of the best energy of interaction, these three molecules could have the most potential antiviral treatment of COVID-19 than the other studied compounds. The structures with best affinity in the binding site of the protease have more than 3 cycles and electronegative atoms in the structure. This may increase the binding affinity of these molecules because of formation of pi-bonds, halogen interactions and/or Hydrogen bond interactions between compounds and the enzyme. So, compounds with more cycles and electronegative atoms could have a potent inhibition of SARS-CoV-2 main protease. |*Molecular Docking Simulation[MESH] |Aminoquinolines/pharmacology[MESH] |Binding Sites/drug effects[MESH] |COVID-19 Drug Treatment[MESH] |Chloroquine/pharmacology[MESH] |Coronavirus 3C Proteases/*antagonists & inhibitors[MESH] |Hydroxychloroquine/pharmacology[MESH] |Imidazoles/chemistry/*pharmacology[MESH] |Molecular Structure[MESH] |Pandemics[MESH] |Protease Inhibitors/*pharmacology[MESH]Assessment of effective imidazole derivatives against SARS-CoV-2 main (epmc).pdf DeepDyve Pubget Overpricing