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10.1016/j.bcp.2020.114225 http://scihub22266oqcxt.onion/10.1016/j.bcp.2020.114225 32956643!7501082!32956643     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32956643&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Biochem+Pharmacol 2020 ; 182 (?): 114225 Nephropedia Template TP {{tp|p=32956643|t=2020. Role of proteolytic enzymes in the COVID-19 infection and promising therapeutic approaches |pdf=|usr=}}{{32956643}} gab.com Text Role of proteolytic enzymes in the COVID-19 infection and promising therapeutic approaches JO: Biochem Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=32956643 #FOAvip In the Fall of 2019 a sudden and dramatic outbreak of a pulmonary disease (Coronavirus Disease COVID-19), due to a new Coronavirus strain (i.e., SARS-CoV-2), emerged in the continental Chinese area of Wuhan and quickly diffused throughout the world, causing up to now several hundreds of thousand deaths. As for common viral infections, the crucial event for the viral life cycle is the entry of genetic material inside the host cell, realized by the spike protein of the virus through its binding to host receptors and its activation by host proteases; this is followed by translation of the viral RNA into a polyprotein, exploiting the host cell machinery. The production of individual mature viral proteins is pivotal for replication and release of new virions. Several proteolytic enzymes either of the host and of the virus act in a concerted fashion to regulate and coordinate specific steps of the viral replication and assembly, such as (i) the entry of the virus, (ii) the maturation of the polyprotein and (iii) the assembly of the secreted virions for further diffusion. Therefore, proteases involved in these three steps are important targets, envisaging that molecules which interfere with their activity are promising therapeutic compounds. In this review, we will survey what is known up to now on the role of specific proteolytic enzymes in these three steps and of most promising compounds designed to impair this vicious cycle. Twit Text FOAVip Role of proteolytic enzymes in the COVID-19 infection and promising therapeutic approaches ????Biochem Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=32956643 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32956643 #FOAvip English Wikipedia <ref>{{Cite pmid|32956643}}</ref> Role of proteolytic enzymes in the COVID-19 infection and promising therapeutic approaches #MMPMID32956643 Gioia M; Ciaccio C; Calligari P; De Simone G; Sbardella D; Tundo G; Fasciglione GF; Di Masi A; Di Pierro D; Bocedi A; Ascenzi P; Coletta M Biochem Pharmacol 2020[Dec]; 182 (?): 114225 PMID32956643show ga In the Fall of 2019 a sudden and dramatic outbreak of a pulmonary disease (Coronavirus Disease COVID-19), due to a new Coronavirus strain (i.e., SARS-CoV-2), emerged in the continental Chinese area of Wuhan and quickly diffused throughout the world, causing up to now several hundreds of thousand deaths. As for common viral infections, the crucial event for the viral life cycle is the entry of genetic material inside the host cell, realized by the spike protein of the virus through its binding to host receptors and its activation by host proteases; this is followed by translation of the viral RNA into a polyprotein, exploiting the host cell machinery. The production of individual mature viral proteins is pivotal for replication and release of new virions. Several proteolytic enzymes either of the host and of the virus act in a concerted fashion to regulate and coordinate specific steps of the viral replication and assembly, such as (i) the entry of the virus, (ii) the maturation of the polyprotein and (iii) the assembly of the secreted virions for further diffusion. Therefore, proteases involved in these three steps are important targets, envisaging that molecules which interfere with their activity are promising therapeutic compounds. In this review, we will survey what is known up to now on the role of specific proteolytic enzymes in these three steps and of most promising compounds designed to impair this vicious cycle. |Animals[MESH] |Antiviral Agents/*therapeutic use[MESH] |COVID-19 Drug Treatment[MESH] |COVID-19/*enzymology[MESH] |Drug Delivery Systems[MESH] |Humans[MESH] |Peptide Hydrolases/*metabolism[MESH] |Protease Inhibitors/*therapeutic use[MESH]Role of proteolytic enzymes in the COVID-19 infection and promising th(epmc).pdf DeepDyve Pubget Overpricing