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10.1093/jpids/piaa117

http://scihub22266oqcxt.onion/10.1093/jpids/piaa117
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32951037!7543556!32951037
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suck abstract from ncbi


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pmid32951037      J+Pediatric+Infect+Dis+Soc 2020 ; 9 (5): 622-625
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  • Defibrotide for the Treatment of Pediatric Inflammatory Multisystem Syndrome Temporally Associated With Severe Acute Respiratory Syndrome Coronavirus 2 Infection in 2 Pediatric Patients #MMPMID32951037
  • Lang P; Eichholz T; Bakchoul T; Streiter M; Petrasch M; Bosmuller H; Klein R; Rabsteyn A; Lang AM; Adams C; Klingel K; Gessner M; Rosenberger P; Ruef P; Handgretinger R
  • J Pediatric Infect Dis Soc 2020[Nov]; 9 (5): 622-625 PMID32951037show ga
  • The pediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus 2 infection is a severe complication of coronavirus disease 2019. Since impaired coagulation and thrombosis/endotheliitis are suspected pathomechanisms, we treated 2 patients with defibrotide, a profibrinolytic, antithrombotic, antiinflammatory oligonucleotide. Symptoms resolved during treatment. Moreover, coagulation parameters indicating hypofibrinolysis and complement activation normalized. The pediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus 2 infection is a severe complication of coronavirus disease 2019. Since impaired coagulation and thrombosis/endotheliitis are suspected pathomechanisms, 2 patients received defibrotide, a profibrinolytic, antithrombotic, antiinflammatory oligonucleotide. Symptoms resolved and hypofibrinolysis/complement activation normalized during treatment.
  • |Abdominal Pain/etiology[MESH]
  • |Adolescent[MESH]
  • |Betacoronavirus[MESH]
  • |Blood Coagulation Factors/analysis[MESH]
  • |COVID-19[MESH]
  • |Child[MESH]
  • |Coronavirus Infections/*complications/diagnosis[MESH]
  • |Female[MESH]
  • |Fever/etiology[MESH]
  • |Humans[MESH]
  • |Pandemics[MESH]
  • |Platelet Aggregation Inhibitors/*therapeutic use[MESH]
  • |Pneumonia, Viral/*complications/diagnosis[MESH]
  • |Polydeoxyribonucleotides/*therapeutic use[MESH]
  • |SARS-CoV-2[MESH]
  • |Systemic Inflammatory Response Syndrome/blood/*drug therapy/immunology[MESH]


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