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10.1016/j.humimm.2020.08.006 http://scihub22266oqcxt.onion/10.1016/j.humimm.2020.08.006 32950268!7495147!32950268     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32950268&cmd=llinks): Failed to open stream: HTTP request failed! 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Characteristics of immune cells and cytokines in patients with coronavirus disease 2019 in Guangzhou, China |pdf=|usr=}}{{32950268}} gab.com Text Characteristics of immune cells and cytokines in patients with coronavirus disease 2019 in Guangzhou, China JO: Hum Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32950268 #FOAvip To discover immune factors that can predict the progression of COVID-19, we evaluated circulating immune cells and plasma cytokines in COVID-19 patients. We found that T cells, including CD4(+) T cells and CD8(+) T cells, were significantly decreased in severe COVID-19 symptoms but not in mild symptoms, in comparison with healthy people. T cells remained at a low level after recovery from severe COVID-19. CD4(+)CD25(+)CD127(low) Treg-enriched cells were significantly increased in either mild or severe COVID-19 patients, regardless of recovery or not. Moreover, in either mild or severe COVID-19 patients, Treg-enriched cells up-regulated CD25 and down-regulated CD127. After recovery, CD25 was partially down-regulated but still higher than the normal level, while CD127 returned to the normal level in mild patients but not severe patients. B cells were decreased in mild patients and further decreased in severe patients, and remained low after recovery. NK cells were decreased only in severe COVID-19, with a tendency to return to the normal level after recovery. Plasma IL-6 and IL-10 were both elevated in severe patients but not in mild patients. After recovery, IL-6 remained higher than its normal level, while IL-10 returned to the normal level. Binary logistic regression analysis indicated that CD4(+) T cells, B cells, IL-6, and IL-10 were significantly associated with COVID-19 severity. Therefore, these parameters are indicators of COVID-19 severity. Dynamic monitoring of these parameters would benefit therapy planning and prognosis evaluation. Twit Text FOAVip Characteristics of immune cells and cytokines in patients with coronavirus disease 2019 in Guangzhou, China ????Hum Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32950268 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32950268 #FOAvip English Wikipedia <ref>{{Cite pmid|32950268}}</ref> Characteristics of immune cells and cytokines in patients with coronavirus disease 2019 in Guangzhou, China #MMPMID32950268 Chen X; Huang J; Huang Y; Chen J; Huang Y; Jiang X; Shi Y Hum Immunol 2020[Dec]; 81 (12): 702-708 PMID32950268show ga To discover immune factors that can predict the progression of COVID-19, we evaluated circulating immune cells and plasma cytokines in COVID-19 patients. We found that T cells, including CD4(+) T cells and CD8(+) T cells, were significantly decreased in severe COVID-19 symptoms but not in mild symptoms, in comparison with healthy people. T cells remained at a low level after recovery from severe COVID-19. CD4(+)CD25(+)CD127(low) Treg-enriched cells were significantly increased in either mild or severe COVID-19 patients, regardless of recovery or not. Moreover, in either mild or severe COVID-19 patients, Treg-enriched cells up-regulated CD25 and down-regulated CD127. After recovery, CD25 was partially down-regulated but still higher than the normal level, while CD127 returned to the normal level in mild patients but not severe patients. B cells were decreased in mild patients and further decreased in severe patients, and remained low after recovery. NK cells were decreased only in severe COVID-19, with a tendency to return to the normal level after recovery. Plasma IL-6 and IL-10 were both elevated in severe patients but not in mild patients. After recovery, IL-6 remained higher than its normal level, while IL-10 returned to the normal level. Binary logistic regression analysis indicated that CD4(+) T cells, B cells, IL-6, and IL-10 were significantly associated with COVID-19 severity. Therefore, these parameters are indicators of COVID-19 severity. Dynamic monitoring of these parameters would benefit therapy planning and prognosis evaluation. |Adult[MESH] |Aged[MESH] |B-Lymphocytes/*immunology[MESH] |COVID-19/blood/epidemiology/*immunology/virology[MESH] |China/epidemiology[MESH] |Female[MESH] |Humans[MESH] |Inflammation/immunology[MESH] |Interleukin-10/*blood[MESH] |Interleukin-6/*blood[MESH] |Killer Cells, Natural/*immunology[MESH] |Lymphocyte Count[MESH] |Male[MESH] |Middle Aged[MESH] |Prognosis[MESH] |SARS-CoV-2/*genetics[MESH] |Severity of Illness Index[MESH] |T-Lymphocytes, Regulatory/*immunology[MESH]Characteristics of immune cells and cytokines in patients with coronav(epmc).pdf DeepDyve Pubget Overpricing