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10.1016/j.ebiom.2020.102999 http://scihub22266oqcxt.onion/10.1016/j.ebiom.2020.102999 32950003!7492814!32950003     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EBioMedicine 2020 ; 60 (ä): 102999 Nephropedia Template TP {{tp|p=32950003|t=2020. Impact of interleukin-6 blockade with tocilizumab on SARS-CoV-2 viral kinetics and antibody responses in patients with COVID-19: A prospective cohort study |pdf=|usr=}}{{32950003}} gab.com Text Impact of interleukin-6 blockade with tocilizumab on SARS-CoV-2 viral kinetics and antibody responses in patients with COVID-19: A prospective cohort study JO: EBioMedicine http://www.kidney.de/pget.php?&tw=1&pmid=32950003 #FOAvip BACKGROUND: The virological and immunological effects of the immunomodulatory drugs used for COVID-19 remain unknown. We evaluated the impact of interleukin (IL)-6 blockade with tocilizumab on SARS-CoV-2 viral kinetics and the antibody response in patients with COVID-19. METHODS: Prospective cohort study in patients admitted with COVID-19. Serial nasopharyngeal and plasma samples were measured for SARS-CoV-2 RNA and S-IgG/N-IgG titers, respectively. FINDINGS: 138 patients with confirmed infection were included; 76 (55%) underwent IL-6 blockade. Median initial SOFA (p = 0*016) and SARS-CoV-2 viral load (p<0*001, Mann-Whitney-Wilcoxon test) were significantly higher among anti-IL-6 users. Patients under IL-6 blockade showed delayed viral clearance in the Kaplan-Meier curves (HR 0*35 [95%CI] [0*15-0*81], log-rank p = 0*014), but an adjusted propensity score matching model did not demonstrate a significant relationship of IL-6 blockade with viral clearance (HR 1*63 [0*35-7*7]). Cox regression showed an inverse association between SARS-CoV-2 RNA clearance and the initial viral load (HR 0*35 [0*11-0*89]). Patients under the IL-6 blocker showed shorter median time to seropositivity, higher peak antibody titers, and higher cumulative proportion of seropositivity in the Kaplan Meier curves (HR 3*1 [1*9-5] for S-IgG; and HR 3*0 [1*9-4*9] for N-IgG; log-rank p<0*001 for both). However, no significant differences between groups were found in either S-IgG (HR 1*56 [0*41-6*0]) nor N-IgG (HR 0*96 [0*26-3*5]) responses in an adjusted propensity score analysis. INTERPRETATION: Our results suggest that in patients infected with SARS-CoV-2, IL-6 blockade does not impair the viral specific antibody responses. Although a delayed viral clearance was observed, it was driven by a higher initial viral load. The study supports the safety of this therapy in patients with COVID-19. FUNDING: Instituto de salud Carlos III (Spain). Twit Text FOAVip Impact of interleukin-6 blockade with tocilizumab on SARS-CoV-2 viral kinetics and antibody responses in patients with COVID-19: A prospective cohort study ????EBioMedicine http://www.kidney.de/pget.php?&tw=1&pmid=32950003 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32950003 #FOAvip English Wikipedia <ref>{{Cite pmid|32950003}}</ref> Impact of interleukin-6 blockade with tocilizumab on SARS-CoV-2 viral kinetics and antibody responses in patients with COVID-19: A prospective cohort study #MMPMID32950003 Masia M; Fernandez-Gonzalez M; Padilla S; Ortega P; Garcia JA; Agullo V; Garcia-Abellan J; Telenti G; Guillen L; Gutierrez F EBioMedicine 2020[Oct]; 60 (ä): 102999 PMID32950003show ga BACKGROUND: The virological and immunological effects of the immunomodulatory drugs used for COVID-19 remain unknown. We evaluated the impact of interleukin (IL)-6 blockade with tocilizumab on SARS-CoV-2 viral kinetics and the antibody response in patients with COVID-19. METHODS: Prospective cohort study in patients admitted with COVID-19. Serial nasopharyngeal and plasma samples were measured for SARS-CoV-2 RNA and S-IgG/N-IgG titers, respectively. FINDINGS: 138 patients with confirmed infection were included; 76 (55%) underwent IL-6 blockade. Median initial SOFA (p = 0*016) and SARS-CoV-2 viral load (p<0*001, Mann-Whitney-Wilcoxon test) were significantly higher among anti-IL-6 users. Patients under IL-6 blockade showed delayed viral clearance in the Kaplan-Meier curves (HR 0*35 [95%CI] [0*15-0*81], log-rank p = 0*014), but an adjusted propensity score matching model did not demonstrate a significant relationship of IL-6 blockade with viral clearance (HR 1*63 [0*35-7*7]). Cox regression showed an inverse association between SARS-CoV-2 RNA clearance and the initial viral load (HR 0*35 [0*11-0*89]). Patients under the IL-6 blocker showed shorter median time to seropositivity, higher peak antibody titers, and higher cumulative proportion of seropositivity in the Kaplan Meier curves (HR 3*1 [1*9-5] for S-IgG; and HR 3*0 [1*9-4*9] for N-IgG; log-rank p<0*001 for both). However, no significant differences between groups were found in either S-IgG (HR 1*56 [0*41-6*0]) nor N-IgG (HR 0*96 [0*26-3*5]) responses in an adjusted propensity score analysis. INTERPRETATION: Our results suggest that in patients infected with SARS-CoV-2, IL-6 blockade does not impair the viral specific antibody responses. Although a delayed viral clearance was observed, it was driven by a higher initial viral load. The study supports the safety of this therapy in patients with COVID-19. FUNDING: Instituto de salud Carlos III (Spain). |Aged[MESH] |Antibodies, Monoclonal, Humanized/*immunology/therapeutic use[MESH] |Antibodies, Viral/blood[MESH] |Antibody Formation[MESH] |Betacoronavirus/isolation & purification/*physiology[MESH] |COVID-19[MESH] |Coronavirus Infections/drug therapy/*pathology/virology[MESH] |Female[MESH] |Humans[MESH] |Immunoglobulin G/blood[MESH] |Interleukin-6/analysis/*immunology[MESH] |Kinetics[MESH] |Male[MESH] |Middle Aged[MESH] |Pandemics[MESH] |Pneumonia, Viral/drug therapy/*pathology/virology[MESH] |Proportional Hazards Models[MESH] |Prospective Studies[MESH] |RNA, Viral/blood[MESH] |SARS-CoV-2[MESH]Impact of interleukin-6 blockade with tocilizumab on SARS-CoV-2 viral (epmc).pdf DeepDyve Pubget Overpricing