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Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Cell+Mol+Med 2020 ; 24 (21): 12864-12868 Nephropedia Template TP
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STAT3 isoforms differentially affect ACE2 expression: A potential target for COVID-19 therapy #MMPMID32949179
Shamir I; Abutbul-Amitai M; Abbas-Egbariya H; Pasmanik-Chor M; Paret G; Nevo-Caspi Y
J Cell Mol Med 2020[Nov]; 24 (21): 12864-12868 PMID32949179show ga
The SARS-coronavirus 2 is the aetiologic agent COVID-19. ACE2 has been identified as a cell entry receptor for the virus. Therefore, trying to understand how the gene is controlled has become a major goal. We silenced the expression of STAT3alpha and STAT3beta, and found that while silencing STAT3alpha causes an increase in ACE2 expression, silencing STAT3beta causes the opposite effect. Studying the role of STAT3 in ACE2 expression will shed light on the molecular events that contribute to the progression of the disease and that the different roles of STAT3alpha and STAT3beta in that context must be taken in consideration. Our results place STAT3 in line with additional potential therapeutic targets for treating COVID-19 patients.