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10.1038/s41587-020-0684-z

http://scihub22266oqcxt.onion/10.1038/s41587-020-0684-z
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32948856!8325066!32948856
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suck abstract from ncbi


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pmid32948856      Nat+Biotechnol 2020 ; 38 (10): 1164-1167
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  • Measurement of SARS-CoV-2 RNA in wastewater tracks community infection dynamics #MMPMID32948856
  • Peccia J; Zulli A; Brackney DE; Grubaugh ND; Kaplan EH; Casanovas-Massana A; Ko AI; Malik AA; Wang D; Wang M; Warren JL; Weinberger DM; Arnold W; Omer SB
  • Nat Biotechnol 2020[Oct]; 38 (10): 1164-1167 PMID32948856show ga
  • We measured severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA concentrations in primary sewage sludge in the New Haven, Connecticut, USA, metropolitan area during the Coronavirus Disease 2019 (COVID-19) outbreak in Spring 2020. SARS-CoV-2 RNA was detected throughout the more than 10-week study and, when adjusted for time lags, tracked the rise and fall of cases seen in SARS-CoV-2 clinical test results and local COVID-19 hospital admissions. Relative to these indicators, SARS-CoV-2 RNA concentrations in sludge were 0-2 d ahead of SARS-CoV-2 positive test results by date of specimen collection, 0-2 d ahead of the percentage of positive tests by date of specimen collection, 1-4 d ahead of local hospital admissions and 6-8 d ahead of SARS-CoV-2 positive test results by reporting date. Our data show the utility of viral RNA monitoring in municipal wastewater for SARS-CoV-2 infection surveillance at a population-wide level. In communities facing a delay between specimen collection and the reporting of test results, immediate wastewater results can provide considerable advance notice of infection dynamics.
  • |*Pandemics[MESH]
  • |*Wastewater-Based Epidemiological Monitoring[MESH]
  • |Betacoronavirus/genetics/*isolation & purification[MESH]
  • |Biotechnology[MESH]
  • |COVID-19[MESH]
  • |Connecticut/epidemiology[MESH]
  • |Coronavirus Infections/*epidemiology[MESH]
  • |Humans[MESH]
  • |Pneumonia, Viral/*epidemiology[MESH]
  • |Prevalence[MESH]
  • |RNA, Viral/*analysis/genetics[MESH]
  • |SARS-CoV-2[MESH]
  • |Sewage/virology[MESH]
  • |Time Factors[MESH]


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