Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText.
Kick-your-searchterm to multiple Engines kick-your-query now !>
A dictionary by aggregated review articles of nephrology, medicine and the life sciences
Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

suck abstract from ncbi


10.1128/mBio.02243-20

http://scihub22266oqcxt.onion/10.1128/mBio.02243-20
suck pdf from google scholar
32948688!7502863!32948688
unlimited free pdf from europmc32948688    free
PDF from PMC    free
html from PMC    free

suck abstract from ncbi


Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
pmid32948688      mBio 2020 ; 11 (5): ä
Nephropedia Template TP

gab.com Text

Twit Text FOAVip

Twit Text #

English Wikipedia


  • Impaired Cytotoxic CD8(+) T Cell Response in Elderly COVID-19 Patients #MMPMID32948688
  • Westmeier J; Paniskaki K; Karakose Z; Werner T; Sutter K; Dolff S; Overbeck M; Limmer A; Liu J; Zheng X; Brenner T; Berger MM; Witzke O; Trilling M; Lu M; Yang D; Babel N; Westhoff T; Dittmer U; Zelinskyy G
  • mBio 2020[Sep]; 11 (5): ä PMID32948688show ga
  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection induces a T cell response that most likely contributes to virus control in COVID-19 patients but may also induce immunopathology. Until now, the cytotoxic T cell response has not been very well characterized in COVID-19 patients. Here, we analyzed the differentiation and cytotoxic profile of T cells in 30 cases of mild COVID-19 during acute infection. SARS-CoV-2 infection induced a cytotoxic response of CD8(+) T cells, but not CD4(+) T cells, characterized by the simultaneous production of granzyme A and B as well as perforin within different effector CD8(+) T cell subsets. PD-1-expressing CD8(+) T cells also produced cytotoxic molecules during acute infection, indicating that they were not functionally exhausted. However, in COVID-19 patients over the age of 80 years, the cytotoxic T cell potential was diminished, especially in effector memory and terminally differentiated effector CD8(+) cells, showing that elderly patients have impaired cellular immunity against SARS-CoV-2. Our data provide valuable information about T cell responses in COVID-19 patients that may also have important implications for vaccine development.IMPORTANCE Cytotoxic T cells are responsible for the elimination of infected cells and are key players in the control of viruses. CD8(+) T cells with an effector phenotype express cytotoxic molecules and are able to perform target cell killing. COVID-19 patients with a mild disease course were analyzed for the differentiation status and cytotoxic profile of CD8(+) T cells. SARS-CoV-2 infection induced a vigorous cytotoxic CD8(+) T cell response. However, this cytotoxic profile of T cells was not detected in COVID-19 patients over the age of 80 years. Thus, the absence of a cytotoxic response in elderly patients might be a possible reason for the more frequent severity of COVID-19 in this age group than in younger patients.
  • |Aged, 80 and over[MESH]
  • |Antigens, CD/metabolism[MESH]
  • |Betacoronavirus/pathogenicity[MESH]
  • |CD4-Positive T-Lymphocytes/immunology/pathology[MESH]
  • |CD8-Positive T-Lymphocytes/immunology/*pathology[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*immunology[MESH]
  • |Cytotoxins/metabolism[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Immunity, Cellular[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*immunology[MESH]
  • |SARS-CoV-2[MESH]
  • |T-Lymphocyte Subsets/immunology/pathology[MESH]


  • DeepDyve
  • Pubget Overpricing
  • suck abstract from ncbi

    Linkout box