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10.3390/cells9092108 http://scihub22266oqcxt.onion/10.3390/cells9092108 32947957!7565802!32947957     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cells 2020 ; 9 (9): ä Nephropedia Template TP {{tp|p=32947957|t=2020. Raloxifene and n-Acetylcysteine Ameliorate TGF-Signalling in Fibroblasts from Patients with Recessive Dominant Epidermolysis Bullosa |pdf=|usr=}}{{32947957}} gab.com Text Raloxifene and n-Acetylcysteine Ameliorate TGF-Signalling in Fibroblasts from Patients with Recessive Dominant Epidermolysis Bullosa JO: Cells http://www.kidney.de/pget.php?&tw=1&pmid=32947957 #FOAvip Recessive dystrophic epidermolysis bullosa (RDEB) is a severe skin disease caused by mutation of the COL7A1 gene. RDEB is associated with high levels of TGF-beta1, which is likely to be involved in the fibrosis that develops in this disease. Endoglin (CD105) is a type III coreceptor for TGF-beta1 and its overexpression in fibroblasts deregulates physiological Smad/Alk1/Alk5 signalling, repressing the synthesis of TGF-beta1 and extracellular matrix (ECM) proteins. Raloxifene is a specific estrogen receptor modulator designated as an orphan drug for hereditary hemorrhagic telangiectasia, a rare vascular disease. Raloxifene stimulates endoglin synthesis, which could attenuate fibrosis. By contrast, the antioxidant N-acetylcysteine may have therapeutic value to rectify inflammation, fibrosis and endothelial dysfunction. Thus, we present here a repurposing strategy based on the molecular and functional screening of fibroblasts from RDEB patients with these drugs, leading us to propose the repositioning of these two well-known drugs currently in clinical use, raloxifene and N-acetylcysteine, to counteract fibrosis and inflammation in RDEB. Both compounds modulate the profibrotic events that may ultimately be responsible for the clinical manifestations in RDEB, suggesting that these findings may also be relevant for other diseases in which fibrosis is an important pathophysiological event. Twit Text FOAVip Raloxifene and n-Acetylcysteine Ameliorate TGF-Signalling in Fibroblasts from Patients with Recessive Dominant Epidermolysis Bullosa ????Cells http://www.kidney.de/pget.php?&tw=1&pmid=32947957 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32947957 #FOAvip English Wikipedia <ref>{{Cite pmid|32947957}}</ref> Raloxifene and n-Acetylcysteine Ameliorate TGF-Signalling in Fibroblasts from Patients with Recessive Dominant Epidermolysis Bullosa #MMPMID32947957 Aguado T; Garcia M; Garcia A; Ferrer-Mayorga G; Martinez-Santamaria L; Del Rio M; Botella LM; Sanchez-Puelles JM Cells 2020[Sep]; 9 (9): ä PMID32947957show ga Recessive dystrophic epidermolysis bullosa (RDEB) is a severe skin disease caused by mutation of the COL7A1 gene. RDEB is associated with high levels of TGF-beta1, which is likely to be involved in the fibrosis that develops in this disease. Endoglin (CD105) is a type III coreceptor for TGF-beta1 and its overexpression in fibroblasts deregulates physiological Smad/Alk1/Alk5 signalling, repressing the synthesis of TGF-beta1 and extracellular matrix (ECM) proteins. Raloxifene is a specific estrogen receptor modulator designated as an orphan drug for hereditary hemorrhagic telangiectasia, a rare vascular disease. Raloxifene stimulates endoglin synthesis, which could attenuate fibrosis. By contrast, the antioxidant N-acetylcysteine may have therapeutic value to rectify inflammation, fibrosis and endothelial dysfunction. Thus, we present here a repurposing strategy based on the molecular and functional screening of fibroblasts from RDEB patients with these drugs, leading us to propose the repositioning of these two well-known drugs currently in clinical use, raloxifene and N-acetylcysteine, to counteract fibrosis and inflammation in RDEB. Both compounds modulate the profibrotic events that may ultimately be responsible for the clinical manifestations in RDEB, suggesting that these findings may also be relevant for other diseases in which fibrosis is an important pathophysiological event. |*Drug Repositioning[MESH] |Acetylcysteine/*pharmacology[MESH] |Activin Receptors, Type II/genetics/metabolism[MESH] |Antioxidants/pharmacology[MESH] |Case-Control Studies[MESH] |Collagen Type VII/genetics/metabolism[MESH] |Endoglin/genetics/metabolism[MESH] |Epidermolysis Bullosa/*genetics/metabolism/pathology[MESH] |Estrogen Antagonists/pharmacology[MESH] |Extracellular Matrix Proteins/genetics/metabolism[MESH] |Fibroblasts/*drug effects/metabolism/pathology[MESH] |Fibrosis[MESH] |Gene Expression Regulation[MESH] |Humans[MESH] |Inheritance Patterns[MESH] |Primary Cell Culture[MESH] |Raloxifene Hydrochloride/*pharmacology[MESH] |Receptor, Transforming Growth Factor-beta Type I/genetics/metabolism[MESH] |Severity of Illness Index[MESH] |Signal Transduction[MESH] |Skin/drug effects/metabolism/pathology[MESH] |Smad Proteins/genetics/metabolism[MESH]Raloxifene and n-Acetylcysteine Ameliorate TGF-Signalling in Fibroblas(epmc).pdf DeepDyve Pubget Overpricing