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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Diagn+Microbiol+Infect+Dis 2020 ; 98 (3): 115161 Nephropedia Template TP
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Retrospective clinical evaluation of 4 lateral flow assays for the detection of SARS-CoV-2 IgG #MMPMID32947206
McAulay K; Bryan A; Greninger AL; Grill F; Lake D; Kaleta EJ; Grys TE
Diagn Microbiol Infect Dis 2020[Nov]; 98 (3): 115161 PMID32947206show ga
In a Clinical Laboratory Improvement Amendments laboratory setting, we evaluated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) IgG detection with 4 lateral flow immunoassays [LFIAs; 2 iterations from BTNX Inc. (n?=?457) and 1 each from ACON Laboratories (n?=?200) and SD BIOSENSOR (n?=?155)]. In a cohort of primarily hospitalized, reverse-transcription polymerase chain reaction-confirmed coronavirus disease 2019 cases, sensitivity at >/=14?days from symptom onset was: BTNX kit 1, 95%; BTNX kit 2, 91%; ACON, 95%; and SD, 92%. All assays showed good concordance with the Abbott SARS-CoV-2 IgG assay at >/=14?days from symptom onset: BTNX kit 1, 99%; BTNX kit 2, 94%; ACON, 99%; and SD, 100%. Specificity, measured using specimens collected prior to SARS-CoV-2 circulation in the United States and "cross-reactivity challenge" specimens, was 98% for BTNX kit 1 and ACON and 100% for BTNX kit 2 and SD. These results suggest that LFIAs may provide adequate results for rapid detection of SARS-CoV-2.