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10.1016/j.drudis.2020.09.010 http://scihub22266oqcxt.onion/10.1016/j.drudis.2020.09.010 32947043!7492153!32947043     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Drug+Discov+Today 2020 ; 25 (11): 2012-22 Nephropedia Template TP {{tp|p=32947043|t=2020. Chloroquine against malaria, cancers and viral diseases |pdf=|usr=}}{{32947043}} gab.com Text Chloroquine against malaria, cancers and viral diseases JO: Drug Discov Today http://www.kidney.de/pget.php?&tw=1&pmid=32947043 #FOAvip Quinoline (QN) derivatives are often used for the prophylaxis and treatment of malaria. Chloroquine (CQ), a protonated, weakly basic drug, exerts its antimalarial effect mainly by increasing pH and accumulating in the food vacuole of the parasites. Repurposing CQ is an emerging strategy for new indications. Given the inhibition of autophagy and its immunomodulatory action, CQ shows positive efficacy against cancer and viral diseases, including Coronavirus 2019 (COVID-19). Here, we review the underlying mechanisms behind the antimalarial, anticancer and antiviral effects of CQ. We also discuss the clinical evidence for the use of CQ and hydroxychloroquine (HCQ) against COVID-19. Twit Text FOAVip Chloroquine against malaria, cancers and viral diseases ????Drug Discov Today http://www.kidney.de/pget.php?&tw=1&pmid=32947043 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32947043 #FOAvip English Wikipedia <ref>{{Cite pmid|32947043}}</ref> Chloroquine against malaria, cancers and viral diseases #MMPMID32947043 Zhou W; Wang H; Yang Y; Chen ZS; Zou C; Zhang J Drug Discov Today 2020[Sep]; 25 (11): 2012-22 PMID32947043show ga Quinoline (QN) derivatives are often used for the prophylaxis and treatment of malaria. Chloroquine (CQ), a protonated, weakly basic drug, exerts its antimalarial effect mainly by increasing pH and accumulating in the food vacuole of the parasites. Repurposing CQ is an emerging strategy for new indications. Given the inhibition of autophagy and its immunomodulatory action, CQ shows positive efficacy against cancer and viral diseases, including Coronavirus 2019 (COVID-19). Here, we review the underlying mechanisms behind the antimalarial, anticancer and antiviral effects of CQ. We also discuss the clinical evidence for the use of CQ and hydroxychloroquine (HCQ) against COVID-19. äChloroquine against malaria, cancers and viral diseases (epmc).pdf DeepDyve Pubget Overpricing