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10.1016/j.celrep.2020.108175 http://scihub22266oqcxt.onion/10.1016/j.celrep.2020.108175 32946807!7470764!32946807     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2020 ; 32 (12): 108175 Nephropedia Template TP {{tp|p=32946807|t=2020. A Single-Cell RNA Expression Map of Human Coronavirus Entry Factors |pdf=|usr=}}{{32946807}} gab.com Text A Single-Cell RNA Expression Map of Human Coronavirus Entry Factors JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=32946807 #FOAvip To predict the tropism of human coronaviruses, we profile 28 SARS-CoV-2 and coronavirus-associated receptors and factors (SCARFs) using single-cell transcriptomics across various healthy human tissues. SCARFs include cellular factors both facilitating and restricting viral entry. Intestinal goblet cells, enterocytes, and kidney proximal tubule cells appear highly permissive to SARS-CoV-2, consistent with clinical data. Our analysis also predicts non-canonical entry paths for lung and brain infections. Spermatogonial cells and prostate endocrine cells also appear to be permissive to SARS-CoV-2 infection, suggesting male-specific vulnerabilities. Both pro- and anti-viral factors are highly expressed within the nasal epithelium, with potential age-dependent variation, predicting an important battleground for coronavirus infection. Our analysis also suggests that early embryonic and placental development are at moderate risk of infection. Lastly, SCARF expression appears broadly conserved across a subset of primate organs examined. Our study establishes a resource for investigations of coronavirus biology and pathology. Twit Text FOAVip A Single-Cell RNA Expression Map of Human Coronavirus Entry Factors ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=32946807 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32946807 #FOAvip English Wikipedia <ref>{{Cite pmid|32946807}}</ref> A Single-Cell RNA Expression Map of Human Coronavirus Entry Factors #MMPMID32946807 Singh M; Bansal V; Feschotte C Cell Rep 2020[Sep]; 32 (12): 108175 PMID32946807show ga To predict the tropism of human coronaviruses, we profile 28 SARS-CoV-2 and coronavirus-associated receptors and factors (SCARFs) using single-cell transcriptomics across various healthy human tissues. SCARFs include cellular factors both facilitating and restricting viral entry. Intestinal goblet cells, enterocytes, and kidney proximal tubule cells appear highly permissive to SARS-CoV-2, consistent with clinical data. Our analysis also predicts non-canonical entry paths for lung and brain infections. Spermatogonial cells and prostate endocrine cells also appear to be permissive to SARS-CoV-2 infection, suggesting male-specific vulnerabilities. Both pro- and anti-viral factors are highly expressed within the nasal epithelium, with potential age-dependent variation, predicting an important battleground for coronavirus infection. Our analysis also suggests that early embryonic and placental development are at moderate risk of infection. Lastly, SCARF expression appears broadly conserved across a subset of primate organs examined. Our study establishes a resource for investigations of coronavirus biology and pathology. |*Virus Internalization[MESH] |A549 Cells[MESH] |Angiotensin-Converting Enzyme 2[MESH] |Animals[MESH] |Betacoronavirus/growth & development[MESH] |COVID-19[MESH] |Cell Line[MESH] |Chlorocebus aethiops[MESH] |Coronavirus Infections/*pathology[MESH] |Enterocytes/metabolism[MESH] |Gene Expression Profiling[MESH] |Goblet Cells/metabolism[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Kidney Tubules, Proximal/cytology/metabolism[MESH] |Nasal Mucosa/*metabolism/virology[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/genetics/metabolism[MESH] |Pneumonia, Viral/*pathology[MESH] |Receptors, Virus/*genetics[MESH] |SARS-CoV-2[MESH] |Serine Endopeptidases/genetics/metabolism[MESH] |Single-Cell Analysis[MESH] |Vero Cells[MESH]A Single-Cell RNA Expression Map of Human Coronavirus Entry Factors (epmc).pdf DeepDyve Pubget Overpricing