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10.1038/s41409-020-01060-5 http://scihub22266oqcxt.onion/10.1038/s41409-020-01060-5 32943758!7498115!32943758     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Bone+Marrow+Transplant 2021 ; 56 (3): 570-580 Nephropedia Template TP {{tp|p=32943758|t=2021. Clinical characterization and risk factors associated with cytokine release syndrome induced by COVID-19 and chimeric antigen receptor T-cell therapy |pdf=|usr=}}{{32943758}} gab.com Text Clinical characterization and risk factors associated with cytokine release syndrome induced by COVID-19 and chimeric antigen receptor T-cell therapy JO: Bone Marrow Transplant http://www.kidney.de/pget.php?&tw=1&pmid=32943758 #FOAvip An excessive immune response during coronavirus disease (COVID-19) can induce cytokine release syndrome (CRS), which is associated with life-threatening complications and disease progression. This retrospective study evaluated the clinical characteristics of severe CRS (sCRS, grade 3-4) induced by severe COVID-19 (40 patients) or chimeric antigen receptor T-cell (CAR-T) therapy as a comparator (41 patients). Grade 4 CRS was significantly more common in the COVID-19 group (15/40 (35.7%) vs. 5/41 (12.2%), P = 0.008). The CAR-T group had more dramatic increase in cytokines, including IL-2, IL-6, IL-10, and IFN-gamma. Interestingly, COVID-19 group had significantly higher levels for TNF-alpha (31.1 pg/ml (16.1-70.0) vs. 3.3 (1.8-9.6), P < 0.001) and lg viral loads were correlated with lg IL-6 (R(2) = 0.101; P < 0.001) and lg IL-10 (R(2) = 0.105; P < 0.001). The independent risk factor for COVID-19-related sCRS was hypertension history (OR: 4.876, 95% CI: 2.038-11.668; P < 0.001). Our study demonstrated that there were similar processes but different intensity of inflammatory responses of sCRS in COVID-19 and CAR-T group. The diagnose and management of severe COVID-19-related sCRS can learn lessons from treatment of sCRS induced by CAR-T therapy. Twit Text FOAVip Clinical characterization and risk factors associated with cytokine release syndrome induced by COVID-19 and chimeric antigen receptor T-cell therapy ????Bone Marrow Transplant http://www.kidney.de/pget.php?&tw=1&pmid=32943758 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32943758 #FOAvip English Wikipedia <ref>{{Cite pmid|32943758}}</ref> Clinical characterization and risk factors associated with cytokine release syndrome induced by COVID-19 and chimeric antigen receptor T-cell therapy #MMPMID32943758 Hong R; Zhao H; Wang Y; Chen Y; Cai H; Hu Y; Wei G; Huang H Bone Marrow Transplant 2021[Mar]; 56 (3): 570-580 PMID32943758show ga An excessive immune response during coronavirus disease (COVID-19) can induce cytokine release syndrome (CRS), which is associated with life-threatening complications and disease progression. This retrospective study evaluated the clinical characteristics of severe CRS (sCRS, grade 3-4) induced by severe COVID-19 (40 patients) or chimeric antigen receptor T-cell (CAR-T) therapy as a comparator (41 patients). Grade 4 CRS was significantly more common in the COVID-19 group (15/40 (35.7%) vs. 5/41 (12.2%), P = 0.008). The CAR-T group had more dramatic increase in cytokines, including IL-2, IL-6, IL-10, and IFN-gamma. Interestingly, COVID-19 group had significantly higher levels for TNF-alpha (31.1 pg/ml (16.1-70.0) vs. 3.3 (1.8-9.6), P < 0.001) and lg viral loads were correlated with lg IL-6 (R(2) = 0.101; P < 0.001) and lg IL-10 (R(2) = 0.105; P < 0.001). The independent risk factor for COVID-19-related sCRS was hypertension history (OR: 4.876, 95% CI: 2.038-11.668; P < 0.001). Our study demonstrated that there were similar processes but different intensity of inflammatory responses of sCRS in COVID-19 and CAR-T group. The diagnose and management of severe COVID-19-related sCRS can learn lessons from treatment of sCRS induced by CAR-T therapy. |*SARS-CoV-2[MESH] |Adult[MESH] |Aged[MESH] |C-Reactive Protein/metabolism[MESH] |COVID-19/*complications/epidemiology/*immunology[MESH] |China/epidemiology[MESH] |Cytokine Release Syndrome/blood/*etiology/immunology[MESH] |Cytokines/blood[MESH] |Female[MESH] |Ferritins/blood[MESH] |Fibrin Fibrinogen Degradation Products/metabolism[MESH] |Humans[MESH] |Immunotherapy, Adoptive/*adverse effects[MESH] |Lung/diagnostic imaging[MESH] |Male[MESH] |Middle Aged[MESH] |Neoplasms/complications/immunology/therapy[MESH] |Pandemics[MESH] |Procalcitonin/blood[MESH] |Prognosis[MESH] |Receptors, Chimeric Antigen/*immunology[MESH] |Retrospective Studies[MESH] |Risk Factors[MESH] |Tumor Burden/immunology[MESH]Clinical characterization and risk factors associated with cytokine re(epmc).pdf DeepDyve Pubget Overpricing