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Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Nat+Commun 2020 ; 11 (1): 4704 Nephropedia Template TP
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A systematic review of antibody mediated immunity to coronaviruses: kinetics, correlates of protection, and association with severity #MMPMID32943637
Nat Commun 2020[Sep]; 11 (1): 4704 PMID32943637show ga
Many public health responses and modeled scenarios for COVID-19 outbreaks caused by SARS-CoV-2 assume that infection results in an immune response that protects individuals from future infections or illness for some amount of time. The presence or absence of protective immunity due to infection or vaccination (when available) will affect future transmission and illness severity. Here, we review the scientific literature on antibody immunity to coronaviruses, including SARS-CoV-2 as well as the related SARS-CoV, MERS-CoV and endemic human coronaviruses (HCoVs). We reviewed 2,452 abstracts and identified 491 manuscripts relevant to 5 areas of focus: 1) antibody kinetics, 2) correlates of protection, 3) immunopathogenesis, 4) antigenic diversity and cross-reactivity, and 5) population seroprevalence. While further studies of SARS-CoV-2 are necessary to determine immune responses, evidence from other coronaviruses can provide clues and guide future research.
|Antibodies, Viral/*immunology[MESH]
|Betacoronavirus/*immunology[MESH]
|COVID-19[MESH]
|Coronavirus Infections/*immunology/therapy[MESH]
|Cross Reactions[MESH]
|Databases, Factual[MESH]
|Humans[MESH]
|Immunization, Passive[MESH]
|Immunoglobulin Isotypes/immunology[MESH]
|Middle East Respiratory Syndrome Coronavirus/immunology[MESH]