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10.1038/s41467-020-18463-z http://scihub22266oqcxt.onion/10.1038/s41467-020-18463-z 32943628!7499305!32943628     free     free     free       Nat+Commun 2020 ; 11 (1): 4682 Nephropedia Template TP {{tp|p=32943628|t=2020. Rapid incorporation of Favipiravir by the fast and permissive viral RNA polymerase complex results in SARS-CoV-2 lethal mutagenesis |pdf=|usr=}}{{32943628}} gab.com Text Rapid incorporation of Favipiravir by the fast and permissive viral RNA polymerase complex results in SARS-CoV-2 lethal mutagenesis JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=32943628 #FOAvip The ongoing Corona Virus Disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has emphasized the urgent need for antiviral therapeutics. The viral RNA-dependent-RNA-polymerase (RdRp) is a promising target with polymerase inhibitors successfully used for the treatment of several viral diseases. We demonstrate here that Favipiravir predominantly exerts an antiviral effect through lethal mutagenesis. The SARS-CoV RdRp complex is at least 10-fold more active than any other viral RdRp known. It possesses both unusually high nucleotide incorporation rates and high-error rates allowing facile insertion of Favipiravir into viral RNA, provoking C-to-U and G-to-A transitions in the already low cytosine content SARS-CoV-2 genome. The coronavirus RdRp complex represents an Achilles heel for SARS-CoV, supporting nucleoside analogues as promising candidates for the treatment of COVID-19. Twit Text FOAVip Rapid incorporation of Favipiravir by the fast and permissive viral RNA polymerase complex results in SARS-CoV-2 lethal mutagenesis ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=32943628 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32943628 #FOAvip English Wikipedia <ref>{{Cite pmid|32943628}}</ref> Rapid incorporation of Favipiravir by the fast and permissive viral RNA polymerase complex results in SARS-CoV-2 lethal mutagenesis #MMPMID32943628 Shannon A; Selisko B; Le NT; Huchting J; Touret F; Piorkowski G; Fattorini V; Ferron F; Decroly E; Meier C; Coutard B; Peersen O; Canard B Nat Commun 2020[Sep]; 11 (1): 4682 PMID32943628show ga The ongoing Corona Virus Disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has emphasized the urgent need for antiviral therapeutics. The viral RNA-dependent-RNA-polymerase (RdRp) is a promising target with polymerase inhibitors successfully used for the treatment of several viral diseases. We demonstrate here that Favipiravir predominantly exerts an antiviral effect through lethal mutagenesis. The SARS-CoV RdRp complex is at least 10-fold more active than any other viral RdRp known. It possesses both unusually high nucleotide incorporation rates and high-error rates allowing facile insertion of Favipiravir into viral RNA, provoking C-to-U and G-to-A transitions in the already low cytosine content SARS-CoV-2 genome. The coronavirus RdRp complex represents an Achilles heel for SARS-CoV, supporting nucleoside analogues as promising candidates for the treatment of COVID-19. |Amides/pharmacokinetics/*pharmacology[MESH] |Animals[MESH] |Antiviral Agents/pharmacokinetics/*pharmacology[MESH] |Betacoronavirus/*drug effects/*genetics[MESH] |COVID-19[MESH] |COVID-19 Drug Treatment[MESH] |Chlorocebus aethiops[MESH] |Coronavirus Infections/*drug therapy/virology[MESH] |Coronavirus RNA-Dependent RNA Polymerase[MESH] |Models, Molecular[MESH] |Mutagenesis/drug effects[MESH] |Pandemics[MESH] |Pneumonia, Viral/*drug therapy/virology[MESH] |Pyrazines/pharmacokinetics/*pharmacology[MESH] |RNA, Viral/genetics/metabolism[MESH] |RNA-Dependent RNA Polymerase/chemistry/metabolism[MESH] |SARS-CoV-2[MESH] |Sequence Analysis[MESH] |Vero Cells[MESH] |Viral Nonstructural Proteins/chemistry/metabolism[MESH]Rapid incorporation of Favipiravir by the fast and permissive viral RN(epmc).pdf DeepDyve Pubget Overpricing