Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1073/pnas.2010540117 http://scihub22266oqcxt.onion/10.1073/pnas.2010540117 32943538!7547220!32943538     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2020 ; 117 (40): 25018-25025 Nephropedia Template TP {{tp|p=32943538|t=2020. Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients |pdf=|usr=}}{{32943538}} gab.com Text Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=32943538 #FOAvip Respiratory failure in the acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is hypothesized to be driven by an overreacting innate immune response, where the complement system is a key player. In this prospective cohort study of 39 hospitalized coronavirus disease COVID-19 patients, we describe systemic complement activation and its association with development of respiratory failure. Clinical data and biological samples were obtained at admission, days 3 to 5, and days 7 to 10. Respiratory failure was defined as PO(2)/FiO(2) ratio of </=40 kPa. Complement activation products covering the classical/lectin (C4d), alternative (C3bBbP) and common pathway (C3bc, C5a, and sC5b-9), the lectin pathway recognition molecule MBL, and antibody serology were analyzed by enzyme-immunoassays; viral load by PCR. Controls comprised healthy blood donors. Consistently increased systemic complement activation was observed in the majority of COVID-19 patients during hospital stay. At admission, sC5b-9 and C4d were significantly higher in patients with than without respiratory failure (P = 0.008 and P = 0.034). Logistic regression showed increasing odds of respiratory failure with sC5b-9 (odds ratio 31.9, 95% CI 1.4 to 746, P = 0.03) and need for oxygen therapy with C4d (11.7, 1.1 to 130, P = 0.045). Admission sC5b-9 and C4d correlated significantly to ferritin (r = 0.64, P < 0.001; r = 0.69, P < 0.001). C4d, sC5b-9, and C5a correlated with antiviral antibodies, but not with viral load. Systemic complement activation is associated with respiratory failure in COVID-19 patients and provides a rationale for investigating complement inhibitors in future clinical trials. Twit Text FOAVip Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=32943538 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32943538 #FOAvip English Wikipedia <ref>{{Cite pmid|32943538}}</ref> Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients #MMPMID32943538 Holter JC; Pischke SE; de Boer E; Lind A; Jenum S; Holten AR; Tonby K; Barratt-Due A; Sokolova M; Schjalm C; Chaban V; Kolderup A; Tran T; Tollefsrud Gjolberg T; Skeie LG; Hesstvedt L; Ormasen V; Fevang B; Austad C; Muller KE; Fladeby C; Holberg-Petersen M; Halvorsen B; Muller F; Aukrust P; Dudman S; Ueland T; Andersen JT; Lund-Johansen F; Heggelund L; Dyrhol-Riise AM; Mollnes TE Proc Natl Acad Sci U S A 2020[Oct]; 117 (40): 25018-25025 PMID32943538show ga Respiratory failure in the acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is hypothesized to be driven by an overreacting innate immune response, where the complement system is a key player. In this prospective cohort study of 39 hospitalized coronavirus disease COVID-19 patients, we describe systemic complement activation and its association with development of respiratory failure. Clinical data and biological samples were obtained at admission, days 3 to 5, and days 7 to 10. Respiratory failure was defined as PO(2)/FiO(2) ratio of |*Complement Activation[MESH] |Aged[MESH] |Betacoronavirus/*immunology[MESH] |Biomarkers/blood[MESH] |COVID-19[MESH] |Case-Control Studies[MESH] |Coronavirus Infections/blood/complications/*immunology[MESH] |Female[MESH] |Host-Pathogen Interactions/immunology[MESH] |Humans[MESH] |Male[MESH] |Mannose-Binding Lectin/blood[MESH] |Middle Aged[MESH] |Pandemics[MESH] |Pneumonia, Viral/blood/complications/*immunology[MESH] |Respiratory Insufficiency/*immunology/virology[MESH] |SARS-CoV-2[MESH]Systemic complement activation is associated with respiratory failure (epmc).pdf DeepDyve Pubget Overpricing