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10.1016/j.vaccine.2020.08.019

http://scihub22266oqcxt.onion/10.1016/j.vaccine.2020.08.019
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suck abstract from ncbi


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pmid32943265      Vaccine 2020 ; 38 (45): 7146-7155
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  • Impact of COVID-19 pandemic response on uptake of routine immunizations in Sindh, Pakistan: An analysis of provincial electronic immunization registry data #MMPMID32943265
  • Chandir S; Siddiqi DA; Mehmood M; Setayesh H; Siddique M; Mirza A; Soundardjee R; Dharma VK; Shah MT; Abdullah S; Akhter MA; Ali Khan A; Khan AJ
  • Vaccine 2020[Oct]; 38 (45): 7146-7155 PMID32943265show ga
  • BACKGROUND: COVID-19 pandemic has affected routine immunization globally. Impact will likely be higher in low and middle-income countries with limited healthcare resources and fragile health systems. We quantified the impact, spatial heterogeneity, and determinants for childhood immunizations of 48 million population affected in the Sindh province of Pakistan. METHODS: We extracted individual immunization records from real-time provincial Electronic Immunization Registry from September 23, 2019, to July 11, 2020. Comparing baseline (6 months preceding the lockdown) and the COVID-19 lockdown period, we analyzed the impact on daily immunization coverage rate for each antigen by geographical area. We used multivariable logistic regression to explore the predictors associated with immunizations during the lockdown. RESULTS: There was a 52.5% decline in the daily average total number of vaccinations administered during lockdown compared to baseline. The highest decline was seen for Bacille Cal-mette Guerin (BCG) (40.6% (958/2360) immunization at fixed sites. Around 8438 children/day were missing immunization during the lockdown. Enrollments declined furthest in rural districts, urban sub-districts with large slums, and polio-endemic super high-risk sub-districts. Pentavalent-3 (penta-3) immunization rates were higher in infants born in hospitals (RR: 1.09; 95% CI: 1.04-1.15) and those with mothers having higher education (RR: 1.19-1.50; 95% CI: 1.13-1.65). Likelihood of penta-3 immunization was reduced by 5% for each week of delayed enrollment into the immunization program. CONCLUSION: One out of every two children in Sindh province has missed their routine vaccinations during the provincial COVID-19 lockdown. The pool of un-immunized children is expanding during lockdown, leaving them susceptible to vaccine-preventable diseases. There is a need for tailored interventions to promote immunization visits and safe service delivery. Higher maternal education, facility-based births, and early enrollment into the immunization program continue to show a positive association with immunization uptake, even during a challenging lockdown.
  • |*Pandemics[MESH]
  • |*Quarantine[MESH]
  • |BCG Vaccine/administration & dosage[MESH]
  • |Betacoronavirus/pathogenicity[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/epidemiology/immunology/*psychology[MESH]
  • |Electronic Data Processing[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Immunization Programs/statistics & numerical data[MESH]
  • |Infant[MESH]
  • |Infant, Newborn[MESH]
  • |Male[MESH]
  • |Measles Vaccine/administration & dosage[MESH]
  • |Measles/epidemiology/immunology/*prevention & control[MESH]
  • |Pakistan/epidemiology[MESH]
  • |Pneumonia, Viral/epidemiology/immunology/*psychology[MESH]
  • |Registries[MESH]
  • |Rotavirus Infections/epidemiology/immunology/*prevention & control[MESH]
  • |Rotavirus Vaccines/administration & dosage[MESH]
  • |Rural Population[MESH]
  • |SARS-CoV-2[MESH]
  • |Tuberculosis, Pulmonary/epidemiology/immunology/*prevention & control[MESH]
  • |Urban Population[MESH]
  • |Vaccination Coverage/statistics & numerical data[MESH]
  • |Vaccination/psychology/*statistics & numerical data[MESH]


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