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10.1016/j.bbrc.2020.08.116 http://scihub22266oqcxt.onion/10.1016/j.bbrc.2020.08.116 32943188!7473028!32943188     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biochem+Biophys+Res+Commun 2021 ; 538 (ä): 47-53 Nephropedia Template TP {{tp|p=32943188|t=2021. RNA-dependent RNA polymerase: Structure, mechanism, and drug discovery for COVID-19 |pdf=|usr=}}{{32943188}} gab.com Text RNA-dependent RNA polymerase: Structure, mechanism, and drug discovery for COVID-19 JO: Biochem Biophys Res Commun http://www.kidney.de/pget.php?&tw=1&pmid=32943188 #FOAvip Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has rapidly become a global pandemic. Although great efforts have been made to develop effective therapeutic interventions, only the nucleotide analog remdesivir was approved for emergency use against COVID-19. Remdesivir targets the RNA-dependent RNA polymerase (RdRp), an essential enzyme for viral RNA replication and a promising drug target for COVID-19. Recently, several structures of RdRp in complex with substrate RNA and remdesivir were reported, providing insights into the mechanisms of RNA recognition by RdRp. These structures also reveal the mechanism of RdRp inhibition by nucleotide inhibitors and offer a molecular template for the development of RdRp-targeting drugs. This review discusses the recognition mechanism of RNA and nucleotide inhibitor by RdRp, and its implication in drug discovery. Twit Text FOAVip RNA-dependent RNA polymerase: Structure, mechanism, and drug discovery for COVID-19 ????Biochem Biophys Res Commun http://www.kidney.de/pget.php?&tw=1&pmid=32943188 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32943188 #FOAvip English Wikipedia <ref>{{Cite pmid|32943188}}</ref> RNA-dependent RNA polymerase: Structure, mechanism, and drug discovery for COVID-19 #MMPMID32943188 Jiang Y; Yin W; Xu HE Biochem Biophys Res Commun 2021[Jan]; 538 (ä): 47-53 PMID32943188show ga Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has rapidly become a global pandemic. Although great efforts have been made to develop effective therapeutic interventions, only the nucleotide analog remdesivir was approved for emergency use against COVID-19. Remdesivir targets the RNA-dependent RNA polymerase (RdRp), an essential enzyme for viral RNA replication and a promising drug target for COVID-19. Recently, several structures of RdRp in complex with substrate RNA and remdesivir were reported, providing insights into the mechanisms of RNA recognition by RdRp. These structures also reveal the mechanism of RdRp inhibition by nucleotide inhibitors and offer a molecular template for the development of RdRp-targeting drugs. This review discusses the recognition mechanism of RNA and nucleotide inhibitor by RdRp, and its implication in drug discovery. |*COVID-19 Drug Treatment[MESH] |*Drug Discovery[MESH] |Adenosine Monophosphate/*analogs & derivatives/chemistry/pharmacology[MESH] |Alanine/*analogs & derivatives/chemistry/pharmacology[MESH] |Antiviral Agents/chemistry/*pharmacology[MESH] |Catalytic Domain[MESH] |Coronavirus RNA-Dependent RNA Polymerase[MESH] |Humans[MESH] |Nucleic Acid Synthesis Inhibitors/chemistry/*pharmacology[MESH] |Protein Conformation[MESH] |RNA, Viral/biosynthesis[MESH] |SARS-CoV-2/*drug effects/enzymology/genetics[MESH]RNA-dependent RNA polymerase: Structure, mechanism, and drug discovery(epmc).pdf DeepDyve Pubget Overpricing