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10.1159/000511325 http://scihub22266oqcxt.onion/10.1159/000511325 32942274!7573917!32942274     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Pathobiology 2021 ; 88 (1): 56-68 Nephropedia Template TP {{tp|p=32942274|t=2021. Autopsy Findings in 32 Patients with COVID-19: A Single-Institution Experience |pdf=|usr=}}{{32942274}} gab.com Text Autopsy Findings in 32 Patients with COVID-19: A Single-Institution Experience JO: Pathobiology http://www.kidney.de/pget.php?&tw=1&pmid=32942274 #FOAvip BACKGROUND: A novel coronavirus, SARS-CoV-2, was identified in Wuhan, China in late 2019. This virus rapidly spread around the world causing disease ranging from minimal symptoms to severe pneumonia, which was termed coronavirus disease (i.e., COVID). Postmortem examination is a valuable tool for studying the pathobiology of this new infection. METHODS: We report the clinicopathologic findings from 32 autopsy studies conducted on patients who died of COVID-19 including routine gross and microscopic examination with applicable special and immunohistochemical staining techniques. RESULTS: SARS-CoV-2 infection was confirmed by nasopharyngeal RT-PCR in 31 cases (97%) and by immunohistochemical staining for SARS-CoV-2 spike-protein in the lung in the remaining 1 case (3%). The ethnically diverse cohort consisted of 22 males and 10 females with a mean age of 68 years (range: 30-100). Patients most commonly presented with cough (17 [55%]), shortness of breath (26 [81%]), and a low-grade fever (17 [55%]). Thirty-one (97%) of the patients had at least 1 comorbidity (mean = 4). Twenty-eight patients (88%) had widespread thromboembolic disease, as well as diffuse alveolar damage (30 [94%]), diabetic nephropathy (17 [57%]) and acute tubular injury. Patterns of liver injury were heterogeneous, featuring 10 (36%) with frequent large basophilic structures in sinusoidal endothelium, and increased immunoblast-like cells in lymph nodes. CONCLUSION: This series of autopsies from patients with COVID-19 confirms the observation that the majority of severely affected patients have significant pulmonary pathology. However, many patients also have widespread microscopic thromboses, as well as characteristic findings in the liver and lymph nodes. Twit Text FOAVip Autopsy Findings in 32 Patients with COVID-19: A Single-Institution Experience ????Pathobiology http://www.kidney.de/pget.php?&tw=1&pmid=32942274 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32942274 #FOAvip English Wikipedia <ref>{{Cite pmid|32942274}}</ref> Autopsy Findings in 32 Patients with COVID-19: A Single-Institution Experience #MMPMID32942274 Elsoukkary SS; Mostyka M; Dillard A; Berman DR; Ma LX; Chadburn A; Yantiss RK; Jessurun J; Seshan SV; Borczuk AC; Salvatore SP Pathobiology 2021[]; 88 (1): 56-68 PMID32942274show ga BACKGROUND: A novel coronavirus, SARS-CoV-2, was identified in Wuhan, China in late 2019. This virus rapidly spread around the world causing disease ranging from minimal symptoms to severe pneumonia, which was termed coronavirus disease (i.e., COVID). Postmortem examination is a valuable tool for studying the pathobiology of this new infection. METHODS: We report the clinicopathologic findings from 32 autopsy studies conducted on patients who died of COVID-19 including routine gross and microscopic examination with applicable special and immunohistochemical staining techniques. RESULTS: SARS-CoV-2 infection was confirmed by nasopharyngeal RT-PCR in 31 cases (97%) and by immunohistochemical staining for SARS-CoV-2 spike-protein in the lung in the remaining 1 case (3%). The ethnically diverse cohort consisted of 22 males and 10 females with a mean age of 68 years (range: 30-100). Patients most commonly presented with cough (17 [55%]), shortness of breath (26 [81%]), and a low-grade fever (17 [55%]). Thirty-one (97%) of the patients had at least 1 comorbidity (mean = 4). Twenty-eight patients (88%) had widespread thromboembolic disease, as well as diffuse alveolar damage (30 [94%]), diabetic nephropathy (17 [57%]) and acute tubular injury. Patterns of liver injury were heterogeneous, featuring 10 (36%) with frequent large basophilic structures in sinusoidal endothelium, and increased immunoblast-like cells in lymph nodes. CONCLUSION: This series of autopsies from patients with COVID-19 confirms the observation that the majority of severely affected patients have significant pulmonary pathology. However, many patients also have widespread microscopic thromboses, as well as characteristic findings in the liver and lymph nodes. |Adult[MESH] |Aged[MESH] |Autopsy/methods[MESH] |COVID-19/pathology/*virology[MESH] |Female[MESH] |Humans[MESH] |Lung/pathology/*virology[MESH] |Male[MESH] |Middle Aged[MESH] |SARS-CoV-2[MESH]Autopsy Findings in 32 Patients with COVID-19: A Single-Institution Ex(epmc).pdf DeepDyve Pubget Overpricing