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10.1016/j.chest.2020.08.2114

http://scihub22266oqcxt.onion/10.1016/j.chest.2020.08.2114
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32941862!7487861!32941862
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suck abstract from ncbi


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pmid32941862      Chest 2021 ; 159 (1): 196-204
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  • Critically Ill Adults With Coronavirus Disease 2019 in New Orleans and Care With an Evidence-Based Protocol #MMPMID32941862
  • Janz DR; Mackey S; Patel N; Saccoccia BP; St Romain M; Busack B; Lee H; Phan L; Vaughn J; Feinswog D; Chan R; Auerbach L; Sausen N; Grace J; Sackey M; Das A; Gordon AO; Schwehm J; McGoey R; Happel KI; Kantrow SP
  • Chest 2021[Jan]; 159 (1): 196-204 PMID32941862show ga
  • BACKGROUND: Characteristics of critically ill adults with coronavirus disease 2019 (COVID-19) in an academic safety net hospital and the effect of evidence-based practices in these patients are unknown. RESEARCH QUESTION: What are the outcomes of critically ill adults with COVID-19 admitted to a network of hospitals in New Orleans, Louisiana, and what is an evidence-based protocol for care associated with improved outcomes? STUDY DESIGN AND METHODS: In this multi-center, retrospective, observational cohort study of ICUs in four hospitals in New Orleans, Louisiana, we collected data on adults admitted to an ICU and tested for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) between March 9, 2020 and April 14, 2020. The exposure of interest was admission to an ICU that implemented an evidence-based protocol for COVID-19 care. The primary outcome was ventilator-free days. RESULTS: The initial 147 patients admitted to any ICU and tested positive for SARS-CoV-2 constituted the cohort for this study. In the entire network, exposure to an evidence-based protocol was associated with more ventilator-free days (25 days; 0-28) compared with non-protocolized ICUs (0 days; 0-23, P = .005), including in adjusted analyses (P = .02). Twenty patients (37%) admitted to protocolized ICUs died compared with 51 (56%; P = .02) in non-protocolized ICUs. Among 82 patients admitted to the academic safety net hospital's ICUs, the median number of ventilator-free days was 22 (interquartile range, 0-27) and mortality rate was 39%. INTERPRETATION: Care of critically ill COVID-19 patients with an evidence-based protocol is associated with increased time alive and free of invasive mechanical ventilation. In-hospital survival occurred in most critically ill adults with COVID-19 admitted to an academic safety net hospital's ICUs despite a high rate of comorbidities.
  • |Aged[MESH]
  • |COVID-19/*therapy[MESH]
  • |Clinical Protocols[MESH]
  • |Cohort Studies[MESH]
  • |Critical Care/*standards[MESH]
  • |Critical Illness[MESH]
  • |Evidence-Based Medicine[MESH]
  • |Female[MESH]
  • |Hospitalization[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |New Orleans[MESH]


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