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10.1016/j.chom.2020.09.002 http://scihub22266oqcxt.onion/10.1016/j.chom.2020.09.002 32941787!7470783!32941787     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Host+Microbe 2020 ; 28 (4): 516-525.e5 Nephropedia Template TP {{tp|p=32941787|t=2020. Human B Cell Clonal Expansion and Convergent Antibody Responses to SARS-CoV-2 |pdf=|usr=}}{{32941787}} gab.com Text Human B Cell Clonal Expansion and Convergent Antibody Responses to SARS-CoV-2 JO: Cell Host Microbe http://www.kidney.de/pget.php?&tw=1&pmid=32941787 #FOAvip B cells are critical for the production of antibodies and protective immunity to viruses. Here we show that patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who develop coronavirus disease 2019 (COVID-19) display early recruitment of B cells expressing a limited subset of IGHV genes, progressing to a highly polyclonal response of B cells with broader IGHV gene usage and extensive class switching to IgG and IgA subclasses with limited somatic hypermutation in the initial weeks of infection. We identify convergence of antibody sequences across SARS-CoV-2-infected patients, highlighting stereotyped naive responses to this virus. Notably, sequence-based detection in COVID-19 patients of convergent B cell clonotypes previously reported in SARS-CoV infection predicts the presence of SARS-CoV/SARS-CoV-2 cross-reactive antibody titers specific for the receptor-binding domain. These findings offer molecular insights into shared features of human B cell responses to SARS-CoV-2 and SARS-CoV. Twit Text FOAVip Human B Cell Clonal Expansion and Convergent Antibody Responses to SARS-CoV-2 ????Cell Host Microbe http://www.kidney.de/pget.php?&tw=1&pmid=32941787 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32941787 #FOAvip English Wikipedia <ref>{{Cite pmid|32941787}}</ref> Human B Cell Clonal Expansion and Convergent Antibody Responses to SARS-CoV-2 #MMPMID32941787 Nielsen SCA; Yang F; Jackson KJL; Hoh RA; Roltgen K; Jean GH; Stevens BA; Lee JY; Rustagi A; Rogers AJ; Powell AE; Hunter M; Najeeb J; Otrelo-Cardoso AR; Yost KE; Daniel B; Nadeau KC; Chang HY; Satpathy AT; Jardetzky TS; Kim PS; Wang TT; Pinsky BA; Blish CA; Boyd SD Cell Host Microbe 2020[Oct]; 28 (4): 516-525.e5 PMID32941787show ga B cells are critical for the production of antibodies and protective immunity to viruses. Here we show that patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who develop coronavirus disease 2019 (COVID-19) display early recruitment of B cells expressing a limited subset of IGHV genes, progressing to a highly polyclonal response of B cells with broader IGHV gene usage and extensive class switching to IgG and IgA subclasses with limited somatic hypermutation in the initial weeks of infection. We identify convergence of antibody sequences across SARS-CoV-2-infected patients, highlighting stereotyped naive responses to this virus. Notably, sequence-based detection in COVID-19 patients of convergent B cell clonotypes previously reported in SARS-CoV infection predicts the presence of SARS-CoV/SARS-CoV-2 cross-reactive antibody titers specific for the receptor-binding domain. These findings offer molecular insights into shared features of human B cell responses to SARS-CoV-2 and SARS-CoV. |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Antibodies, Viral/blood/genetics/*immunology[MESH] |Antibody Formation[MESH] |B-Lymphocytes/*immunology[MESH] |Betacoronavirus/genetics/*immunology[MESH] |COVID-19[MESH] |Coronavirus Infections/*immunology/*virology[MESH] |Female[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Immunogenetics[MESH] |Immunoglobulin A/genetics/immunology[MESH] |Immunoglobulin G/genetics/immunology[MESH] |Male[MESH] |Middle Aged[MESH] |Pandemics[MESH] |Pneumonia, Viral/*immunology/*virology[MESH] |SARS-CoV-2[MESH] |Sequence Analysis[MESH]Human B Cell Clonal Expansion and Convergent Antibody Responses to SAR(epmc).pdf DeepDyve Pubget Overpricing