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10.4269/ajtmh.20-0986

http://scihub22266oqcxt.onion/10.4269/ajtmh.20-0986
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32940201!7646754!32940201
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suck abstract from ncbi


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pmid32940201      Am+J+Trop+Med+Hyg 2020 ; 103 (5): 1783-1796
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  • Extrapulmonary Clinical Manifestations in COVID-19 Patients #MMPMID32940201
  • Sarkesh A; Daei Sorkhabi A; Sheykhsaran E; Alinezhad F; Mohammadzadeh N; Hemmat N; Bannazadeh Baghi H
  • Am J Trop Med Hyg 2020[Nov]; 103 (5): 1783-1796 PMID32940201show ga
  • COVID-19 manifestations in symptomatic patients can be in the form of pneumonia, acute respiratory syndrome, and multiple organ dysfunction as well. Renal complications, gastrointestinal dysfunctions, endocrine system disorders, myocardial dysfunction and arrhythmia, neurological dysfunctions, dermatological symptoms, hematological manifestations, and thromboinflammation are among the reported extrapulmonary complications. Moreover, the presence of coagulopathy, excessive and dysregulated immune responses, and autoimmunity by COVID-19 patients is considerable. The pathogenesis of infection entails the entry of the virus via receptors on cells, principally angiotensin-converting enzyme 2 receptors. Direct virus damage coupled with indirect effects of viral infection including thromboinflammation, dysfunction of the immune system, and dysregulation of the renin-angiotensin system leads to multiple organ failure. This review outlines the extrapulmonary organ-specific complications and their pathophysiology and epidemiology.
  • |*Renin-Angiotensin System[MESH]
  • |Angiotensin-Converting Enzyme 2[MESH]
  • |Betacoronavirus/pathogenicity[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*complications[MESH]
  • |Humans[MESH]
  • |Immune System/*physiopathology/virology[MESH]
  • |Inflammation/physiopathology/virology[MESH]
  • |Pandemics[MESH]
  • |Peptidyl-Dipeptidase A[MESH]
  • |Pneumonia, Viral/*complications[MESH]


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